College of Chemistry, Nanchang University, Nanchang 330031, PR China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
Mater Sci Eng C Mater Biol Appl. 2017 Dec 1;81:321-326. doi: 10.1016/j.msec.2017.08.009. Epub 2017 Aug 3.
ZnO has been widely investigated as important biomaterials and antibacterial materials. However, the aggregation of nanoparticles and its potential toxicity may hinder its final application. Herein, biocompatible gelatin chains were grafted on the surface of ZnO via mussel inspired method to prevent the aggregation of the ZnO nanoparticles. The in vitro test showed that the gelatin can greatly improve the biocompatibility of ZnO, while the antibacterial properties of ZnO against both E. coli and S. aureus were maintained.
氧化锌作为一种重要的生物材料和抗菌材料已经得到了广泛的研究。然而，纳米颗粒的聚集及其潜在的毒性可能会阻碍其最终应用。在此，通过贻贝启发的方法将生物相容性的明胶链接枝到氧化锌表面，以防止氧化锌纳米颗粒的聚集。体外实验表明，明胶可以大大提高氧化锌的生物相容性，同时保持氧化锌对大肠杆菌和金黄色葡萄球菌的抗菌性能。
