Department of Dental Hygiene, Division of Health Science, Baekseok University, Cheonan, Republic of Korea.
Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, 50-1 Yonsei-Ro, Seodaemun-Gu, Seoul, 03722, Republic of Korea.
Sci Rep. 2022 Nov 14;12(1):19456. doi: 10.1038/s41598-022-24172-y.
Colonization of auto-polymerized acrylic resin by pathogenic Candida albicans is a common problem for denture users. In this study, zinc-modified phosphate-based glass was introduced into an auto-polymerized acrylic resin at concentrations of 3, 5, and 7 wt.%. The mechanical or physical properties (flexural strength, elastic modulus, microhardness, and contact angle), surface morphology of the resultant materials, and the antimicrobial effect on C. albicans were investigated. There were no statistical differences in the mechanical properties between the control and the zinc-modified phosphate-based glass samples (p > 0.05); however, the number of C. albicans colony-forming units was significantly lower in the control group (p < 0.05). Scanning electron microscopy revealed that C. albicans tended not to adhere to the zinc-modified-phosphate-based glass samples. Thus, the zinc-modified materials retained the advantageous mechanical properties of unaltered acrylic resins, while simultaneously exhibiting a strong antimicrobial effect in vitro.
白色念珠菌对自聚合丙烯酸树脂的定植是义齿使用者的常见问题。在这项研究中，将锌改性磷酸盐玻璃以 3、5 和 7wt%的浓度引入自聚合丙烯酸树脂中。研究了所得材料的机械或物理性能（弯曲强度、弹性模量、显微硬度和接触角）、表面形态以及对白色念珠菌的抗菌作用。在机械性能方面，对照组和锌改性磷酸盐玻璃样品之间没有统计学差异（p＞0.05）；然而，对照组的白色念珠菌菌落形成单位数量明显较低（p＜0.05）。扫描电子显微镜显示，白色念珠菌不易黏附在锌改性磷酸盐玻璃样品上。因此，改性材料保留了未改性丙烯酸树脂的有利机械性能，同时在体外表现出强烈的抗菌作用。
