Zhang Yun, Li Xiaojing, Li Jia, Khan Md Zaved Hossain, Ma Fanyi, Liu Xiuhua
Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, School of Pharmacy, Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China.
Department of Chemical Engineering, Jashore University of Science and Technology, Jahsore, 7408, Bangladesh.
BMC Chem. 2021 Mar 15;15(1):17. doi: 10.1186/s13065-021-00745-2.
In order to enhance the antibacterial activity and reduce the toxicity of Zn, novel complexes of Zn(II) were synthesized.
A water-soluble zinc-glucose-citrate complex (ZnGC) with antibacterial activity was synthesized at pH 6.5. The structure, morphology, characterization, acute toxicity, antibacterial and antioxidant activities, and in situ intestinal absorption were investigated. The results showed that zinc ion was linked with citrate by coordinate bond while the glucose was linked with it through intermolecular hydrogen bonding. The higher the molecular weight of sugar is, the more favorable it is to inhibit the formation of zinc citrate precipitation. Compared with ZnCl, ZnGC complex presented better antibacterial activity against Staphylococcus aureus (S. aureus, Gram-positive) and Escherichia coli (E. coli, Gram-negative).
The results of acute toxicity showed no obvious toxicity in this test and in situ intestinal absorption study, suggesting that ZnGC complex could be used as a potential zinc supplement for zinc deficiency.
为增强锌的抗菌活性并降低其毒性，合成了新型锌（II）配合物。
在pH 6.5条件下合成了具有抗菌活性的水溶性锌-葡萄糖-柠檬酸盐配合物（ZnGC）。对其结构、形态、表征、急性毒性、抗菌和抗氧化活性以及原位肠道吸收进行了研究。结果表明，锌离子通过配位键与柠檬酸盐相连，而葡萄糖通过分子间氢键与之相连。糖的分子量越高，越有利于抑制柠檬酸锌沉淀的形成。与ZnCl相比，ZnGC配合物对金黄色葡萄球菌（革兰氏阳性菌）和大肠杆菌（革兰氏阴性菌）表现出更好的抗菌活性。
急性毒性试验和原位肠道吸收研究结果表明，该配合物在本试验中无明显毒性，提示ZnGC配合物可作为潜在的锌缺乏症锌补充剂。
