英国医院分离的阴沟肠杆菌菌株的血清型和生化特征与感染部位及抗生素敏感性的关系

Serotypes and biochemical profiles of British hospital strains of Enterobacter cloacae in relation to site of infection and antibiotic susceptibility.

作者信息

Gaston M A, Crees-Morris J A, Pitt T L

机构信息

Division of Hospital Infection, Central Public Health Laboratory, London, UK.

出版信息

J Hosp Infect. 1987 Jul;10(1):17-27. doi: 10.1016/0195-6701(87)90028-4.

DOI:10.1016/0195-6701(87)90028-4

PMID:2888807

Abstract

Comparisons were made between the O-serotype, API 20E profile, site of isolation and antimicrobial resistance of clinical isolates of Enterobacter cloacae. Correlations were found between autoagglutinable strains and urinary-tract infection, and API 20E profile 3305573 and strains isolated from blood. The proportion of strains sensitive to amikacin, gentamicin, cefotaxime, cefuroxime and trimethoprim were 100%, 93%, 91%, 83% and 89%, respectively. No individual resistances or patterns of resistance were associated with O-serotype or biochemical profile. Strains isolated from urinary-tract infections were the most resistant, 40% being resistant to five or more antimicrobials compared to 18%, 12% and 4% for strains from blood, wounds and sputum, respectively. There were no readily identifiable phenotypes within E. cloacae that possessed unique characteristics that could contribute to infections in hospitals.

摘要

对阴沟肠杆菌临床分离株的O血清型、API 20E谱型、分离部位及抗菌药物耐药性进行了比较。发现自凝菌株与尿路感染之间存在相关性，API 20E谱型3305573与血液中分离出的菌株之间存在相关性。对阿米卡星、庆大霉素、头孢噻肟、头孢呋辛和甲氧苄啶敏感的菌株比例分别为100%、93%、91%、83%和89%。没有个体耐药性或耐药模式与O血清型或生化谱型相关。从尿路感染中分离出的菌株耐药性最强，40%的菌株对五种或更多抗菌药物耐药，而从血液、伤口和痰液中分离出的菌株这一比例分别为18%、12%和4%。在阴沟肠杆菌中没有易于识别的具有独特特征且可能导致医院感染的表型。