增加水果和蔬菜的摄入量可以减轻肥胖人群的氧化损伤和相关炎症反应，而与体重变化无关。

Increased Fruit and Vegetable Consumption Mitigates Oxidative Damage and Associated Inflammatory Response in Obese Subjects Independent of Body Weight Change.

机构信息

Internal Medicine, College of Medicine & Health Sciences, United Arab Emirates University, Al-Ain P.O. Box 15551, United Arab Emirates.

出版信息

Nutrients. 2023 Mar 28;15(7):1638. doi: 10.3390/nu15071638.

DOI:10.3390/nu15071638

PMID:37049477

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10096720/

Abstract

INTRODUCTION

The growing prevalence of obesity and related type 2 diabetes is reaching epidemic proportions in the Gulf countries. Oxidative damage and inflammation are possible mechanisms linking obesity to diabetes and other related complications, including cardiovascular disease (CVD).

AIMS

To measure the effects of increased fruit and vegetable consumption on body weight, waist circumference, oxidative damage, and inflammatory markers.

MATERIALS AND METHODS

We recruited and followed up with 965 community free-living subjects. All recruited subjects had fruit and vegetable intakes, physical activity, antioxidants, and markers of oxidative damage and inflammation measured at baseline and follow up. A validated, semi-quantitative food-frequency questionnaire was used to assess subjects' fruit and vegetable consumption. We stratified subjects based on their daily fruit and vegetable consumption and compared metabolic risk factors between those with high fruit and vegetable consumption and those with low consumption. A multiple logistic regression analysis was performed to determine the independent effects of fruit and vegetable intake on changes in body weight and waist circumference (WC).

RESULTS

A total of 965 community free-living subjects (801 (83%) females, mean (SD) age 39 ± 12 years) were recruited and followed up with for a mean (SD) period of 427 ± 223 days. Using WHO cut-off points for body mass index (BMI), 284 (30%) subjects were overweight and 584 (62%) obese, compared to 69 (8%) at normal body weight. An increased fruit and vegetable consumption was associated with a significant decrease in inflammatory markers (hs CRP, TNF-α) and oxidative damage markers (TBARs) and with increased antioxidant enzymes (catalase, glutathione peroxidase) compared to a low consumption ( < 0.05). The benefits of an increased fruit and vegetable consumption in obese subjects was independent of changes in body weight and WC and was maintained at follow up.

CONCLUSION

Our results support the beneficial role of a higher fruit and vegetable intake in obese subjects independent of changes in body weight and WC.

摘要

简介

在海湾国家，肥胖症和相关 2 型糖尿病的患病率不断上升，已达到流行程度。氧化损伤和炎症可能是肥胖与糖尿病和其他相关并发症（包括心血管疾病）联系的机制。

目的

测量增加水果和蔬菜摄入量对体重、腰围、氧化损伤和炎症标志物的影响。

材料和方法

我们招募并随访了 965 名社区自由生活的受试者。所有招募的受试者在基线和随访时都测量了水果和蔬菜摄入量、体力活动、抗氧化剂以及氧化损伤和炎症标志物。使用经过验证的半定量食物频率问卷来评估受试者的水果和蔬菜摄入量。我们根据他们的日常水果和蔬菜摄入量对受试者进行分层，并比较高水果和蔬菜摄入量与低摄入量的受试者之间的代谢风险因素。进行多因素逻辑回归分析以确定水果和蔬菜摄入量对体重和腰围（WC）变化的独立影响。

结果

共招募了 965 名社区自由生活的受试者（801 名（83%）女性，平均（SD）年龄 39 ± 12 岁），并随访了平均（SD）427 ± 223 天。使用世界卫生组织（WHO）体重指数（BMI）切点，284 名（30%）受试者超重，584 名（62%）肥胖，而正常体重的只有 69 名（8%）。与低摄入量相比，增加水果和蔬菜的摄入量与炎症标志物（hsCRP、TNF-α）和氧化损伤标志物（TBARs）的显著降低以及抗氧化酶（过氧化氢酶、谷胱甘肽过氧化物酶）的增加相关（<0.05）。与体重和 WC 变化无关，肥胖受试者增加水果和蔬菜摄入量的益处在随访时仍然存在。