School of Public Health, College of Public health, Taipei Medical University, 250 Wu-Hsin Street, Taipei 110, Taiwan.
School of Public Health, College of Public health, Taipei Medical University, 250 Wu-Hsin Street, Taipei 110, Taiwan; Department of Public Health, College of Public health, China Medical University, 91 Hsueh-Shih Road, Taichung 404, Taiwan.
Reprod Toxicol. 2017 Dec;74:77-84. doi: 10.1016/j.reprotox.2017.09.001. Epub 2017 Sep 7.
Endometriosis is an inflammatory disease associated with multiple pathogenic factors and studies regarding roles of trace metals in endometriosis have been inconsistent and limited. The aim of this cross-sectional study was to compare the blood levels of miscellaneous trace metals measured by inductively coupled plasma mass spectrometry in infertile women with and without endometriosis. Zinc level is associated with declining odds (adjusted OR=0.39, 95% CI=0.18-0.88) of endometriosis. By contrast, lead level is associated with increasing odds (adjusted OR=2.59, 95% CI=1.11-6.06) of endometriosis. The cadmium levels were higher in women with endometriosis, but the aOR was not significant. Zinc has anti-inflammatory characteristics and regulates homeostasis of zinc-containing superoxide dismutase. High lead levels might induce reactive oxygen species and deplete antioxidant defense mechanisms. Further prospective study is needed to test for their causal associations.
子宫内膜异位症是一种与多种致病因素相关的炎症性疾病，有关痕量金属在子宫内膜异位症中的作用的研究一直存在不一致和局限性。本横断面研究的目的是比较患有和未患有子宫内膜异位症的不孕妇女血液中通过电感耦合等离子体质谱法测量的多种痕量金属的水平。锌水平与子宫内膜异位症患病几率降低相关（调整后的 OR=0.39，95%CI=0.18-0.88）。相比之下，铅水平与子宫内膜异位症患病几率升高相关（调整后的 OR=2.59，95%CI=1.11-6.06）。患有子宫内膜异位症的女性体内的镉水平较高，但优势比无统计学意义。锌具有抗炎特性，并调节含锌超氧化物歧化酶的体内平衡。高水平的铅可能会诱导活性氧并耗尽抗氧化防御机制。需要进一步的前瞻性研究来检验它们的因果关系。
