纽约县成人原发性干燥综合征的发病率和患病率。
The Incidence and Prevalence of Adult Primary Sjögren's Syndrome in New York County.
机构信息
New York University School of Medicine, New York, New York.
Harbor-University of California Medical Center, Los Angeles.
出版信息
Arthritis Care Res (Hoboken). 2019 Jul;71(7):949-960. doi: 10.1002/acr.23707. Epub 2019 May 23.
OBJECTIVE
Extant epidemiologic data of primary Sjögren's syndrome (SS) remains limited, particularly for racial/ethnic populations in the US. The Manhattan Lupus Surveillance Program (MLSP) is a population-based retrospective registry of cases of systemic lupus erythematosus and related diseases, including primary SS in Manhattan, New York. The MLSP was used to provide estimates of the incidence and prevalence of primary SS across major racial/ethnic populations.
METHODS
MLSP cases were identified from hospitals, rheumatologists, and population databases. Three case definitions were used for primary SS, including physician diagnosis, rheumatologist diagnosis, and modified primary SS criteria. Rates among Manhattan residents were age-adjusted, and capture-recapture analyses were conducted to assess underascertainment of cases.
RESULTS
By physician diagnosis, age-adjusted overall incidence and prevalence rates of primary SS among adult Manhattan residents were 3.5 and 13.1 per 100,000 person-years, respectively. Capture-recapture adjustment increased incidence and prevalence rates (4.1 and 14.2 per 100,000 person-years, respectively). Based on physician diagnosis, incidence and prevalence rates were approximately 6 times higher among women than men (P < 0.001). Incidence of primary SS was statistically higher among non-Latina Asian women (10.5) and non-Latina white women (6.2) compared with Latina women (3.2). Incidence was also higher among non-Latina Asian women compared with non-Latina black women (3.3). Prevalence of primary SS did not differ by race/ethnicity. Similar trends were observed when more restrictive case definitions were applied.
CONCLUSION
Data from the MLSP revealed disparities among Manhattan residents in primary SS incidence and prevalence by sex and differences in primary SS incidence by race/ethnicity among women. These data also provided epidemiologic estimates for the major racial/ethnic populations in the US.
目的
原发性干燥综合征（SS）的现有流行病学数据仍然有限，尤其是在美国的种族/民族人群中。曼哈顿狼疮监测计划（MLSP）是一个基于人群的回顾性系统性红斑狼疮及相关疾病病例登记处，包括纽约曼哈顿的原发性 SS。MLSP 用于提供主要种族/民族人群中原发性 SS 的发病率和患病率估计。
方法
从医院、风湿病学家和人群数据库中确定 MLSP 病例。使用三种原发性 SS 的病例定义，包括医生诊断、风湿病学家诊断和改良原发性 SS 标准。曼哈顿居民的比率进行了年龄调整，并进行捕获-再捕获分析以评估病例的漏报情况。
结果
根据医生诊断，成年曼哈顿居民的原发性 SS 总体发病率和患病率经年龄调整后分别为每 100000 人年 3.5 和 13.1 例。捕获-再捕获调整增加了发病率和患病率（分别为每 100000 人年 4.1 和 14.2 例）。根据医生诊断，原发性 SS 的发病率在女性中比男性高约 6 倍（P < 0.001）。与拉丁裔女性（3.2）相比，非拉丁裔亚裔女性（10.5）和非拉丁裔白人女性（6.2）的原发性 SS 发病率统计学上更高。与非拉丁裔黑人女性（3.3）相比，非拉丁裔亚裔女性的发病率也更高。原发性 SS 的患病率不因种族/民族而异。当应用更严格的病例定义时，也观察到类似的趋势。
结论
MLSP 的数据显示，曼哈顿居民原发性 SS 的发病率和患病率存在性别差异，女性原发性 SS 的发病率存在种族/民族差异。这些数据还为美国主要种族/民族人群提供了流行病学估计。
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