Liu Litong, Nagai Izumi, Gao Ying, Matsushima Yoshibumi, Kawai Yoshichika, Sayama Kazutoshi
a Graduate School of Science and Technology , Shizuoka University , Shizuoka , Japan.
b College of Agriculture , Academic Institute, Shizuoka University , Shizuoka , Japan.
Biosci Biotechnol Biochem. 2017 Oct;81(10):1948-1955. doi: 10.1080/09168451.2017.1364618. Epub 2017 Sep 11.
Atherosclerosis is one of the diseases related to metabolic syndrome which is caused by obesity. Previous reports have shown that green tea and its components have anti-obesity effect. We examined whether catechins and caffeine can prevent the development of atherosclerosis by oral administration, singly or in combination to the atherosclerosis model mice. Results demonstrated that the number of atherosclerotic regions in the aorta was significantly reduced by the combined treatment, and the atherosclerotic area was also improved. Serum HDL-C increased by caffeine single treatment, but no effect on the TG and TC by any treatments. Moreover, ECG illuviated to atheromatous lesions in aorta and the illuviation was enhanced by caffeine. The mRNA expression levels of LOX-1 and TNF-α showed a tendency to suppress by the combined treatment. These results indicated that the combined administration of catechins and caffeine has the inhibitory effect on the development of atherosclerosis in mice.
动脉粥样硬化是一种与由肥胖引起的代谢综合征相关的疾病。先前的报告表明，绿茶及其成分具有抗肥胖作用。我们研究了儿茶素和咖啡因单独或联合口服给药对动脉粥样硬化模型小鼠动脉粥样硬化发展的预防作用。结果表明，联合治疗可显著减少主动脉中动脉粥样硬化区域的数量，且动脉粥样硬化面积也得到改善。咖啡因单一治疗可使血清高密度脂蛋白胆固醇（HDL-C）升高，但任何治疗对甘油三酯（TG）和总胆固醇（TC）均无影响。此外，心电图显示主动脉出现动脉粥样硬化病变，且咖啡因可增强这种病变。联合治疗使凝集素样氧化型低密度脂蛋白受体1（LOX-1）和肿瘤坏死因子-α（TNF-α）的mRNA表达水平呈现出抑制趋势。这些结果表明，儿茶素和咖啡因联合给药对小鼠动脉粥样硬化的发展具有抑制作用。
