Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, FI-20520, Turku, Finland.
Turku Centre for Biotechnology, Åbo Akademi University and University of Turku, FI-20520, Turku, Finland.
Adv Healthc Mater. 2017 Nov;6(21). doi: 10.1002/adhm.201700258. Epub 2017 Sep 11.
Approaches to increase the efficiency in developing drugs and diagnostics tools, including new drug delivery and diagnostic technologies, are needed for improved diagnosis and treatment of major diseases and health problems such as cancer, inflammatory diseases, chronic wounds, and antibiotic resistance. Development within several areas of research ranging from computational sciences, material sciences, bioengineering to biomedical sciences and bioimaging is needed to realize innovative drug development and diagnostic (DDD) approaches. Here, an overview of recent progresses within key areas that can provide customizable solutions to improve processes and the approaches taken within DDD is provided. Due to the broadness of the area, unfortunately all relevant aspects such as pharmacokinetics of bioactive molecules and delivery systems cannot be covered. Tailored approaches within (i) bioinformatics and computer-aided drug design, (ii) nanotechnology, (iii) novel materials and technologies for drug delivery and diagnostic systems, and (iv) disease models to predict safety and efficacy of medicines under development are focused on. Current developments and challenges ahead are discussed. The broad scope reflects the multidisciplinary nature of the field of DDD and aims to highlight the convergence of biological, pharmaceutical, and medical disciplines needed to meet the societal challenges of the 21st century.
需要采用新的药物输送和诊断技术等方法来提高药物和诊断工具的开发效率，从而改善癌症、炎症性疾病、慢性伤口和抗生素耐药性等重大疾病和健康问题的诊断和治疗水平。需要在计算科学、材料科学、生物工程到生物医学科学和生物成像等多个研究领域开展工作，以实现创新药物开发和诊断（DDD）方法。本文概述了关键领域的最新进展，这些进展可以为改进 DDD 中的流程和方法提供定制化的解决方案。由于该领域非常广泛，因此很遗憾无法涵盖所有相关方面，如生物活性分子和输送系统的药代动力学。本文重点介绍了（i）生物信息学和计算机辅助药物设计、（ii）纳米技术、（iii）用于药物输送和诊断系统的新型材料和技术，以及（iv）疾病模型，以预测正在开发的药物的安全性和疗效。本文讨论了当前的发展和未来的挑战。如此广泛的范围反映了 DDD 领域的多学科性质，旨在强调为应对 21 世纪的社会挑战所需的生物、制药和医学学科的融合。
