Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO 63110, USA; Center for Clinical Pharmacology, St. Louis College of Pharmacy and Washington University School of Medicine, St. Louis, MO 63110, USA; Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Electrical, Computer, and Energy Engineering, University of Colorado Boulder, CO 80309, USA; Materials Science and Engineering Program, University of Colorado Boulder, CO 80309, USA.
Curr Opin Pharmacol. 2017 Oct;36:78-85. doi: 10.1016/j.coph.2017.08.010. Epub 2017 Sep 9.
Site-specific drug delivery carries many advantages of systemic administration, but is rarely used in the clinic. One limiting factor is the relative invasiveness of the technology to locally deliver compounds. Recent advances in materials science and electrical engineering allow for the development of ultraminiaturized microfluidic channels based on soft materials to create flexible probes capable of deep tissue targeting. A diverse set of mechanics, including micro-pumps and functional materials, used to deliver the drugs can be paired with wireless electronics for self-contained and programmable operation. These first iterations of minimally invasive fluid delivery devices foreshadow important advances needed for clinical translation.
局部给药具有许多优于全身给药的优势，但在临床上很少使用。一个限制因素是该技术局部给药的相对侵入性。材料科学和电气工程的最新进展允许基于软材料开发超小型微流控通道，从而创建能够进行深层组织靶向的柔性探头。可以将一套不同的机械装置（包括微泵和功能材料）与无线电子设备结合使用，用于输送药物，实现自给自足和可编程操作。这些微创流体输送装置的最初迭代预示着临床转化所需的重要进展。
