Bhat Venkatraman, Velandai Sundararaman, Belliappa Vikram, Illayraja Jeyeram, Halli Karthik Gadabana, Gopalakrishnan Gayathri
Senior Consultant, Department of Radiology, Narayana Health, Shaw Mazumdar Medical Center, Bengaluru, Karnataka, India.
Senior Scientist, Department of Medical Imaging, Philips Inovation Campus, Bengaluru, Karnataka, India.
J Clin Diagn Res. 2017 Jul;11(7):TC06-TC10. doi: 10.7860/JCDR/2017/26317.10234. Epub 2017 Jul 1.
Accurate, non-invasive method of fat estimation is a valuable test for evaluation of diseases with abnormal hepatic fat.
To determine the accuracy of mDixon MR technique in assessment of liver fat over CT and to correlate the CT and MRI findings with biopsy.
A prospective observational study was conducted at Imaging Services of Narayana Multispeciality Hospital between March 2011- December 2012. Thirty patients who attended the clinic for non-hepatic complaints were included in the study. Patients with known liver disease, cirrhosis, alcoholic liver disease, bleeding diathesis and claustrophobic patients were excluded from the study. Subjects underwent sonography, CT liver and MR examination of liver for fat estimation using mDixon protocol. Biopsy of the liver was performed either by image guidance or by direct biopsy. Liver Attenuation Index (LAI), fat estimation by MR methods were reviewed independently by two observers and compared with biopsy results. The statistical analysis was performed by SPSS. Pearson correlation was used to find the correlation between the left and right lobe of liver segments by CT and histological correlation.
There was good correlation between the MR estimation of liver fat and histological grading. Majority (90%) of patients had fat content of less than 10%. Maximal fat content of 28% was observed in one patient. LAI values poorly correlated with the MRI and histological observations.
MR estimation of the liver using mDixon technique yielded specific information about liver fat, correlated well with the histological grading. Technique is more accurate than CT, does not involve ionising radiation, hence recommended as method of choice.
准确、无创的脂肪评估方法对于评估伴有肝脏脂肪异常的疾病是一项有价值的检测。
确定mDixon磁共振成像（MR）技术在评估肝脏脂肪方面相对于计算机断层扫描（CT）的准确性，并将CT和MRI结果与活检结果进行关联。
2011年3月至2012年12月在纳拉亚纳多专科医院影像科进行了一项前瞻性观察研究。纳入30名因非肝脏疾病前来就诊的患者。已知患有肝脏疾病、肝硬化、酒精性肝病、出血性疾病的患者以及幽闭恐惧症患者被排除在研究之外。受试者接受了超声检查、肝脏CT和使用mDixon方案进行肝脏脂肪评估的MR检查。肝脏活检通过图像引导或直接活检进行。两名观察者独立复查肝脏衰减指数（LAI）以及通过MR方法进行的脂肪评估，并与活检结果进行比较。使用社会科学统计软件包（SPSS）进行统计分析。采用Pearson相关性分析来确定CT测量的肝脏左右叶之间的相关性以及与组织学的相关性。
肝脏脂肪的MR评估与组织学分级之间存在良好的相关性。大多数（90%）患者的脂肪含量低于10%。一名患者的最大脂肪含量为28%。LAI值与MRI和组织学观察结果的相关性较差。
使用mDixon技术进行肝脏MR评估可得出有关肝脏脂肪的具体信息，与组织学分级相关性良好。该技术比CT更准确，不涉及电离辐射，因此推荐作为首选方法。
