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类风湿关节炎中的免疫球蛋白λ轻链基因

Immunoglobulin lambda light chain genes in rheumatoid arthritis.

作者信息

Sidebottom D, Grennan D M, Sanders P A, Read A

机构信息

University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK.

出版信息

Ann Rheum Dis. 1987 Aug;46(8):587-9. doi: 10.1136/ard.46.8.587.

DOI:10.1136/ard.46.8.587
PMID:2889427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1002204/
Abstract

Restriction fragment length polymorphisms (RFLPs) obtained by hybridisation of an immunoglobulin lambda constant region probe to Eco RI digests of genomic deoxyribonucleic acid (DNA) obtained from rheumatoid arthritis (RA) and control subjects have been compared. Polymorphic bands of 8, 13, 18, and 23 kb (kilobases) were shown. The 8/8 genotype and 8 kb allele were increased and the 8/18 genotype and 18 kb allele decreased in the RA group. This effect was independent of HLA and Gm. These findings suggest that genes linked to the loci for the immunoglobulin lambda constant region may influence susceptibility to RA.

摘要

通过将免疫球蛋白λ恒定区探针与从类风湿性关节炎（RA）患者和对照受试者获得的基因组脱氧核糖核酸（DNA）的Eco RI酶切片段进行杂交，得到了限制性片段长度多态性（RFLP），并进行了比较。结果显示出8、13、18和23千碱基（kb）的多态性条带。在RA组中，8/8基因型和8 kb等位基因增加，而8/18基因型和18 kb等位基因减少。这种效应独立于HLA和Gm。这些发现表明，与免疫球蛋白λ恒定区基因座连锁的基因可能影响对RA的易感性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bda1/1002204/051089d692fd/annrheumd00287-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bda1/1002204/051089d692fd/annrheumd00287-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bda1/1002204/051089d692fd/annrheumd00287-0020-a.jpg

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引用本文的文献

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HLA-linked rheumatoid arthritis.HLA相关的类风湿关节炎。
Am J Hum Genet. 1994 Oct;55(4):738-46.
2
Altered immunoglobulin concentrations and light chain ratios in juvenile onset mixed connective tissue disease.青少年起病的混合性结缔组织病中免疫球蛋白浓度及轻链比例的改变
Clin Rheumatol. 1995 Jan;14(1):51-4. doi: 10.1007/BF02208084.
3
Kappa/lambda immunoglobulin distribution in Graves' thyroid-stimulating antibodies. Simultaneous analysis of C lambda gene polymorphisms.格雷夫斯病促甲状腺抗体中的κ/λ免疫球蛋白分布。Cλ基因多态性的同步分析。

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