Kaya Aygünoğlu Selma, Çelebi Arif, Vardar Nilgün, Gürsoy Esra
Clinic of Neurology, Okmeydanı Training and Research Hospital, İstanbul, Turkey.
Department of Neurology, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey.
Noro Psikiyatr Ars. 2015 Sep;52(3):247-251. doi: 10.5152/npa.2015.8714. Epub 2015 Jul 7.
Fatigue is a subjective and non-specific symptom; therefore, evaluation of fatigue is quite difficult. Fatigue has been reported in 75%-87% of patients with multiple sclerosis (MS) and two-thirds of these patients indicated fatigue as one of the worst three common symptoms that they experienced. This study was conducted to measure the intensity, frequency and the characteristics of fatigue in patients with MS. Moreover, the effect of fatigue on the quality of life and its association with depression and disability were evaluated.
One hundred and twenty patients with multiple sclerosis (84 women and 36 men) were included in our study. The patients' sociodemographic characteristics and their experiences on symptoms of fatigue were questioned. Presence and degree of fatigue were assessed using the fatigue severity scale (FSS). Disability status was detected with expanded disability status scale (EDSS). The Multiple Sclerosis Quality of Life (MSQoL-54) survey was conducted to evaluate the quality of life of patients and Beck Depression Inventory (BDI) was used to determine the current depression status. Patients were grouped into fatigue and non-fatigue groups based on FSS. Both groups were compared according to their age, sex, MS clinical types, course of the disease and scores of EDSS, BDI and MSQoL-54.
Seventy percent of patients reported fatigue and 38% of these patients defined fatigue as their most disabling symptom. There was no correlation of fatigue with age, sex and disease duration. The correlation of fatigue and educational level was negative and weak (p<.05, r=-.214) and the correlation between fatigue and MS clinical types were significant but weak (p<.01, r=.228). Patients with fatigue had higher EDSS and BDI scores. In addition, FSS scores were found to be statistically meaningful and positively correlated with both EDSS and BDI scores (r=.404, r=.476, p<.01). Furthermore, our findings revealed that the quality of life in patients with MS and fatigue was poor (r=-.58 p<.01). Similarly, a negative connection was found between MSQoL-54 sub-scales and fatigue.
This study proved that fatigue has a positive correlation with depression and disability and a negative significant relation with the quality of life of patients with MS.
疲劳是一种主观且非特异性的症状；因此，对疲劳进行评估相当困难。据报道，75%-87%的多发性硬化症（MS）患者存在疲劳症状，其中三分之二的患者表示疲劳是他们所经历的最严重的三种常见症状之一。本研究旨在测量MS患者疲劳的强度、频率及特征。此外，还评估了疲劳对生活质量的影响及其与抑郁和残疾的关联。
本研究纳入了120例多发性硬化症患者（84名女性和36名男性）。询问了患者的社会人口学特征以及他们在疲劳症状方面的经历。使用疲劳严重程度量表（FSS）评估疲劳的存在及程度。用扩展残疾状态量表（EDSS）检测残疾状况。进行多发性硬化症生活质量（MSQoL-54）调查以评估患者的生活质量，并使用贝克抑郁量表（BDI）确定当前的抑郁状态。根据FSS将患者分为疲劳组和非疲劳组。比较两组患者的年龄、性别、MS临床类型、病程以及EDSS、BDI和MSQoL-54的得分。
70%的患者报告有疲劳症状，其中38%的患者将疲劳定义为最致残的症状。疲劳与年龄、性别和病程无相关性。疲劳与教育水平呈负相关且较弱（p<0.05，r=-0.214），疲劳与MS临床类型之间的相关性显著但较弱（p<0.01，r=0.228）。疲劳患者的EDSS和BDI得分更高。此外，发现FSS得分具有统计学意义，且与EDSS和BDI得分均呈正相关（r=0.404，r=0.476，p<0.01）。此外，我们的研究结果显示，有疲劳症状的MS患者生活质量较差（r=-0.58，p<0.01）。同样，在MSQoL-54子量表与疲劳之间发现了负相关关系。
本研究证明，疲劳与抑郁和残疾呈正相关，与MS患者的生活质量呈显著负相关。
