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以脑脓肿为表现的食管鳞状细胞癌

Esophageal Squamous Cell Carcinoma Presenting with Cerebral Abscess.

作者信息

Nayfe Rabih, Ascha Mustafa S, Rehmus Esther H

机构信息

Department of Geriatrics, UT Southwestern Medical Center, Dallas, TX, USA.

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.

出版信息

Case Rep Pathol. 2017;2017:5819676. doi: 10.1155/2017/5819676. Epub 2017 Aug 15.

Abstract

BACKGROUND

Cerebral abscess is caused by inoculation of an organism into the brain parenchyma from a site distant from the central nervous system. is a commensal organism that is normally present in the aerodigestive tract and was reported to be the cause of brain abscesses after esophageal dilatation or upper endoscopy.

CASE PRESENTATION

We report the case of a 53-year-old female who presented with hematemesis and melena followed by left-sided weakness. Initially, her hemiplegia was found to be secondary to a right thalamic brain abscess caused by . Investigations led to the diagnosis of a mid-esophageal squamous cell carcinoma. We hypothesize that the cause of the abscess with this bacterium that naturally resides in the digestive tract and oral cavity is secondary to hematogenous spread from breach in the mucosal integrity from ulceration due to the cancer.

CONCLUSION

To our knowledge, our case is the first in the literature to describe a brain abscess caused by in association with a previously undiagnosed esophageal squamous cell carcinoma without any prior esophageal intervention.

摘要

背景

脑脓肿是由生物体从远离中枢神经系统的部位接种到脑实质引起的。[某种细菌名称]是一种共生生物体,通常存在于气消化道中,据报道在食管扩张或上消化道内镜检查后可导致脑脓肿。

病例报告

我们报告一例53岁女性病例,该患者先出现呕血和黑便,随后出现左侧肢体无力。最初,发现她的偏瘫继发于由[某种细菌名称]引起的右侧丘脑脑脓肿。检查诊断为食管中段鳞状细胞癌。我们推测,这种自然存在于消化道和口腔中的细菌导致脓肿的原因是癌症引起的溃疡导致黏膜完整性破坏,进而血行播散所致。

结论

据我们所知,我们的病例是文献中首例描述由[某种细菌名称]引起的脑脓肿,且与先前未诊断出的食管鳞状细胞癌相关,且无任何先前食管干预史。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d49/5574295/89c4efd403c6/CRIPA2017-5819676.001.jpg

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