Morita E, Narikiyo M, Yokoyama A, Yano A, Kamoi K, Yoshikawa E, Yamaguchi T, Igaki H, Tachimori Y, Kato H, Saito D, Hanada N, Sasaki H
Department of Oral Health, National Institute of Public Health, Wako-shi, Japan.
Oral Microbiol Immunol. 2005 Dec;20(6):362-5. doi: 10.1111/j.1399-302X.2005.00242.x.
Chronic alcohol consumption is known to be a major risk factor for cancers of the upper aerodigestive tract. The incidence of esophageal cancer (4.4%) in alcoholics is reported to be much higher than that in the Japanese population as a whole (0.0001%). This suggests the presence of specific factors in chronic alcohol consumption-related carcinogenesis. Recently, data showing a significant correlation between Streptococcus anginosus and carcinogenesis in the upper aerodigestive tract have been reported. In this study, the ratio of S. anginosus to oral bacteria in the saliva of 38 alcoholic patients was investigated to determine if there is an association between alcoholic patients and S. anginosus infection. The level of S. anginosus in the saliva from 22 healthy people, 41 esophageal cancer patients, 32 gastritis patients, and 24 periodontitis patients was also investigated and compared to the level in alcoholic patients. In the saliva from esophageal cancer patients, the level of S. anginosus was not significantly different from that of healthy people. The levels of S. anginosus in periodontitis and gastritis patients were also similar. In alcoholics, however, there was an extremely high level of S. anginosus, suggesting that they, rather than healthy people and general esophageal cancer patients, have a high risk for S. anginosus infection.
长期饮酒是上消化道癌症的主要危险因素。据报道，酗酒者中食管癌的发病率（4.4%）远高于日本总人口的发病率（0.0001%）。这表明在与长期饮酒相关的致癌过程中存在特定因素。最近，有数据报道了咽峡炎链球菌与上消化道致癌之间存在显著相关性。在本研究中，调查了38例酗酒患者唾液中咽峡炎链球菌与口腔细菌的比例，以确定酗酒患者与咽峡炎链球菌感染之间是否存在关联。还调查了22名健康人、41名食管癌患者、32名胃炎患者和24名牙周炎患者唾液中咽峡炎链球菌的水平，并与酗酒患者的水平进行比较。在食管癌患者的唾液中，咽峡炎链球菌的水平与健康人没有显著差异。牙周炎和胃炎患者中咽峡炎链球菌的水平也相似。然而，在酗酒者中，咽峡炎链球菌的水平极高，这表明与健康人和一般食管癌患者相比，酗酒者感染咽峡炎链球菌的风险更高。
