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Jikken Dobutsu. 1986 Jan;35(1):29-33. doi: 10.1538/expanim1978.35.1_29.
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Dopamine depletion impairs gait automaticity by altering cortico-striatal and cerebellar processing in Parkinson's disease.多巴胺耗竭通过改变帕金森病患者的皮质-纹状体和小脑处理来损害步态自动性。
Neuroimage. 2017 May 15;152:207-220. doi: 10.1016/j.neuroimage.2017.02.073. Epub 2017 Mar 3.
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Arch Neurol. 1984 Jun;41(6):612-4. doi: 10.1001/archneur.1984.04210080020007.
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Simultaneous quantification of dopamine, serotonin, their metabolites and amino acids by LC-MS/MS in mouse brain following repetitive transcranial magnetic stimulation.采用 LC-MS/MS 对重复经颅磁刺激后小鼠脑内多巴胺、5-羟色胺及其代谢产物和氨基酸的同时定量分析。
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Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies.LRRK2 帕金森病运动前期的 5-羟色胺和多巴胺转运体 PET 变化：横断面研究。
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1
Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits.小脑和下丘脑功能的年龄相关变化伴随着非小胶质细胞免疫基因表达、突触组织改变以及兴奋性氨基酸神经传递缺陷。
Aging (Albany NY). 2016 Sep 20;8(9):2153-2181. doi: 10.18632/aging.101040.
2
Serotonergic modulation of intrinsic functional connectivity.血清素能调制内在功能连接。
Curr Biol. 2014 Oct 6;24(19):2314-8. doi: 10.1016/j.cub.2014.08.024. Epub 2014 Sep 18.
3
Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans.血清素和神经肽 PDF 在秀丽隐杆线虫中启动并延长对立的行为状态。
Cell. 2013 Aug 29;154(5):1023-1035. doi: 10.1016/j.cell.2013.08.001. Epub 2013 Aug 22.
4
Using a million cell simulation of the cerebellum: network scaling and task generality.使用小脑的百万细胞模拟：网络缩放和任务通用性。
Neural Netw. 2013 Nov;47:95-102. doi: 10.1016/j.neunet.2012.11.005. Epub 2012 Nov 20.
5
The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex.中间神经元在小脑皮层浦肯野细胞反应形成中的作用。
J Neurosci. 2011 Jul 20;31(29):10463-73. doi: 10.1523/JNEUROSCI.1350-11.2011.
6
Risk of falls in 85-year-olds is associated with functional and cognitive status: the Octabaix Study.85 岁老年人的跌倒风险与功能和认知状态有关：Octabaix 研究。
Arch Gerontol Geriatr. 2012 Mar-Apr;54(2):352-6. doi: 10.1016/j.archger.2011.06.004. Epub 2011 Jun 30.
7
Gait speed and survival in older adults.老年人的步速与生存。
JAMA. 2011 Jan 5;305(1):50-8. doi: 10.1001/jama.2010.1923.
8
Age-related predictors of institutionalization: results of the German study on ageing, cognition and dementia in primary care patients (AgeCoDe).与年龄相关的住院预测因素：初级保健患者老龄化、认知和痴呆的德国研究（AgeCoDe）的结果。
Soc Psychiatry Psychiatr Epidemiol. 2012 Feb;47(2):263-70. doi: 10.1007/s00127-010-0333-9. Epub 2010 Dec 23.
9
A realistic large-scale model of the cerebellum granular layer predicts circuit spatio-temporal filtering properties.一个真实的小脑颗粒层大规模模型预测了电路时空滤波特性。
Front Cell Neurosci. 2010 May 14;4:12. doi: 10.3389/fncel.2010.00012. eCollection 2010.
10
Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force.常速步行速度可预测社区居住老年人的不良结局：国际营养与衰老学会（IANA）工作组的报告
J Nutr Health Aging. 2009 Dec;13(10):881-9. doi: 10.1007/s12603-009-0246-z.

老年C57BL/6小鼠全小脑5-羟色胺增加。

Increased whole cerebellar serotonin in aged C57BL/6 mice.

作者信息

DeKorver Nicholas W, Lichty Dustin, van der Hart Marieke, Rassoulpour Arash, Bonasera Stephen J

机构信息

Internal Medicine, University of Nebraska Medical Center; Microdialysis, Brains Online.

出版信息

Matters (Zur). 2017;2017. doi: 10.19185/matters.201702000011. Epub 2017 Mar 9.

DOI:10.19185/matters.201702000011
PMID:28894740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5591457/
Abstract

Mobility and locomotor impairments have high prevalence, morbidity, and significant mortality in older adult populations. Cerebellar functional changes have been implicated in the pathogenesis of these age-related mobility and gait deficits unrelated to stroke, Parkinson's disease, or degenerative joint disease. We thus examined total cerebellar glutamate, glutamine, GABA, glycine, dopamine, norepinephrine, tryptophan, serotonin, alanine, threonine, and asparagine content from male 2-3-month (young, = 6) and 21-24-month-old (aged, = 6) CBL/6 mice. Neurotransmitter and amino acid concentrations were determined by high-performance liquid chromatography followed with mass spectroscopy. We found a significant increase in cerebellar serotonin in aged versus young mice, but otherwise no significant phenotypic differences in measured neurotransmitter concentrations. Applying current thought about cerebellar aging and cerebellar serotonergic systems, we consider how this age-related increase in cerebellar serotonin may contribute to gait ataxia.

摘要

行动能力和运动障碍在老年人群中具有很高的患病率、发病率和显著的死亡率。小脑功能变化与这些与中风、帕金森病或退行性关节病无关的年龄相关行动能力和步态缺陷的发病机制有关。因此，我们检测了2至3个月大（年轻组，n = 6）和21至24个月大（老年组，n = 6）的C57BL/6雄性小鼠小脑内谷氨酸、谷氨酰胺、γ-氨基丁酸、甘氨酸、多巴胺、去甲肾上腺素、色氨酸、5-羟色胺、丙氨酸、苏氨酸和天冬酰胺的总量。通过高效液相色谱-质谱联用测定神经递质和氨基酸浓度。我们发现老年小鼠小脑内5-羟色胺显著增加，而所测神经递质浓度在其他方面无显著表型差异。根据当前有关小脑衰老和小脑5-羟色胺能系统的观点，我们探讨了小脑5-羟色胺的这种年龄相关增加可能如何导致步态共济失调。