Department of Radiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Division of Advanced Medicine Promotion, The Advanced Clinical Research Centre, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Eur Radiol. 2018 Feb;28(2):692-697. doi: 10.1007/s00330-017-5037-z. Epub 2017 Sep 11.
To directly investigate the rapid respiratory effect of gadoxetate disodium in an experimental study using mice.
After confirming the steady respiratory state under general anaesthesia, eight mice were injected with all test agents in the following order: phosphate-buffered saline (A, control group), 1.25 mmol/kg of gadoteridol (B) or gadopentetate dimeglumine (C), or 0.31 mmol/kg of gadoxetate disodium (D, E). The experimenter was not blinded to the agents. The injection dose was fixed as 100 μL for Groups A-D and 50 μL for Group E. We continuously monitored and recorded respiratory rate (RR), peripheral oxygen saturation (SpO), and heart rate. The time-series changes from 0 to 30 s were compared by the linear mixed method RESULTS: Groups D and E showed the largest RR increase (20.6 and 20.3 breaths/min, respectively) and were significantly larger compared to Group A (3.36 breaths/min, both P<0.001). RR change of Groups D and E did not differ. RR change of Groups B and C was smaller (0.72 and 12.4 breaths/min, respectively) and did not differ statistically with Group A. Significant bradycardia was observed only in Group C (P<0.001). SpO was constant in all groups.
Gadoxetate disodium causes a rapid tachypnoea without significant change of SpO and heart rate regardless of the dilution method.
• Injection of gadoxetate disodium causes tachypnoea. • Dilution method did not alter the rapid respiratory effect of gadoxetate disodium. • The respiratory effect of gadoxetate disodium was larger than other contrast agents.
在一项使用小鼠的实验研究中，直接研究钆塞酸二钠的快速呼吸效应。
在全身麻醉下确认稳定的呼吸状态后，将 8 只小鼠按以下顺序注射所有测试药物：磷酸盐缓冲盐水（A，对照组）、1.25mmol/kg 钆特醇（B）或钆喷替酸二甲葡胺（C）或 0.31mmol/kg 钆塞酸二钠（D、E）。实验者对药物不设盲。各注射剂量均固定为 A、B、C 组 100μL，E 组 50μL。我们连续监测和记录呼吸频率（RR）、外周血氧饱和度（SpO）和心率。采用线性混合模型比较 0 至 30s 的时间序列变化。
D 组和 E 组的 RR 增加最大（分别为 20.6 和 20.3 次/分钟），与 A 组（3.36 次/分钟，均 P<0.001）相比显著增加。D 组和 E 组的 RR 变化无差异。B 组和 C 组的 RR 变化较小（分别为 0.72 和 12.4 次/分钟），与 A 组无统计学差异。仅 C 组观察到显著的心动过缓（P<0.001）。所有组的 SpO 均保持不变。
无论稀释方法如何，钆塞酸二钠均可引起快速性呼吸急促，而 SpO 和心率无明显变化。
• 注射钆塞酸二钠可引起呼吸急促。• 稀释方法并未改变钆塞酸二钠的快速呼吸作用。• 钆塞酸二钠的呼吸作用大于其他对比剂。
