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牛乳铁蛋白通过与硫酸乙酰肝素、低密度脂蛋白受体和 DC-SIGN 相互作用来抑制登革病毒感染性。

Bovine Lactoferrin Inhibits Dengue Virus Infectivity by Interacting with Heparan Sulfate, Low-Density Lipoprotein Receptor, and DC-SIGN.

机构信息

Graduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung 40227, Taiwan.

出版信息

Int J Mol Sci. 2017 Sep 12;18(9):1957. doi: 10.3390/ijms18091957.

DOI:10.3390/ijms18091957
PMID:28895925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5618606/
Abstract

Bovine lactoferrin (bLF) presents in milk and has been shown to inhibit several viral infections. Effective drugs are unavailable for the treatment of dengue virus (DENV) infection. In this study, we evaluated the antiviral effect of bLF against DENV infection in vivo and in vitro. Bovine LF significantly inhibited the infection of the four serotypes of DENV in Vero cells. In the time-of-drug addition test, DENV-2 infection was remarkably inhibited when bLF was added during or prior to the occurrence of virus attachment. We also revealed that bovine LF blocks binding between DENV-2 and the cellular membrane by interacting with heparan sulfate (HS), dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN), and low-density lipoprotein receptors (LDLR). In addition, bLF inhibits DENV-2 infection and decreases morbidity in a suckling mouse challenge model. This study supports the finding that bLF may inhibit DENV infection by binding to the potential DENV receptors.

摘要

牛乳铁蛋白（bLF）存在于牛奶中，已被证明可抑制多种病毒感染。目前尚无有效的药物可用于治疗登革热病毒（DENV）感染。在这项研究中，我们评估了 bLF 对体内和体外 DENV 感染的抗病毒作用。牛 LF 显著抑制了 Vero 细胞中四种血清型 DENV 的感染。在药物添加时间测试中，当 bLF 在病毒附着发生时或之前添加时，DENV-2 感染明显受到抑制。我们还揭示牛 LF 通过与肝素硫酸盐（HS）、树突状细胞特异性细胞间黏附分子 3 抓取非整合素（DC-SIGN）和低密度脂蛋白受体（LDLR）相互作用来阻断 DENV-2 与细胞膜之间的结合。此外，bLF 抑制 DENV-2 感染并降低乳鼠攻毒模型的发病率。这项研究支持了 bLF 可能通过与潜在的 DENV 受体结合来抑制 DENV 感染的发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/042f/5618606/bcc0974c5802/ijms-18-01957-g005.jpg
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