Hamsten A, Iselius L, de Faire U, Blombäck M
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Lancet. 1987 Oct 31;2(8566):988-91. doi: 10.1016/s0140-6736(87)92557-8.
Genetic and cultural heritability of plasma fibrinogen concentration was estimated by path analysis with environmental indices in 85 families identified by means of probands with early myocardial infarction and in 85 families randomly selected from the general population. A substantial proportion of the variance of the plasma fibrinogen level, 51%, was accounted for by genetic heritability, whereas the cultural heritability was negligible. No intergenerational differences were indicated in genetic or cultural heritability. The combined effect of obesity and smoking was found to explain 3% of the variance of the plasma fibrinogen level. The demonstration of such substantial genetic control further supports the view that plasma fibrinogen is a primary risk factor for CHD rather than a reflection of the severity of manifest disease.
通过路径分析，利用环境指数对85个由早期心肌梗死先证者确定的家庭以及85个从普通人群中随机选取的家庭的血浆纤维蛋白原浓度的遗传和文化遗传性进行了估计。血浆纤维蛋白原水平变异的很大一部分（51%）可由遗传遗传性解释，而文化遗传性可忽略不计。在遗传或文化遗传性方面未显示出代际差异。发现肥胖和吸烟的综合作用可解释血浆纤维蛋白原水平变异的3%。这种显著的遗传控制的证明进一步支持了血浆纤维蛋白原是冠心病主要危险因素而非明显疾病严重程度反映的观点。
