Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
Department of Breast and Thyroid Surgery, Affiliated Nanshan Hospital, Guangdong Medical University, Shenzhen, China.
Sci Rep. 2017 Sep 12;7(1):11412. doi: 10.1038/s41598-017-11788-8.
The prognostic significance of gender remains controversial for papillary thyroid carcinoma (PTC). In this study, we investigated the associations between gender and prognosis in a large cohort of patients with PTC or PTMC that was diagnosed in 2010-2013 and recorded in the Surveillance, Epidemiology, and End Results cancer registry. The mean ± standard deviation duration of survival for all patients with PTC during the study period was 21.47 ± 14.04 months. In Kaplan-Meier analyses of the entire cohort of PTC patients, survival curves for all-cause death and cancer-specific death declined more sharply for men than for women. Similar results were observed in analyses of patients with PTCs > 1 cm and PTMC. After adjusting for potential confounders, hazard rates indicated significantly elevated all-cause mortality for men in analyses of all PTCs, PTCs > 1 cm, and PTMCs. However, in a confounder-adjusted analysis of patients with PTMC, the hazard rate did not indicate significantly higher mortality for men than for women. Our study demonstrated that male gender is an independent poor prognostic factor for all PTCs and for PTCs > 1 cm. However, gender is not an independent prognostic factor for cause-specific survival in PTMC.
性别对甲状腺乳头状癌（PTC）的预后意义仍存在争议。本研究调查了 2010-2013 年间确诊于监测、流行病学和最终结果癌症登记处的大量 PTC 或微浸润性甲状腺癌（PTMC）患者中性别与预后的关系。在研究期间，所有 PTC 患者的平均生存时间±标准差为 21.47±14.04 个月。在整个 PTC 患者队列的 Kaplan-Meier 分析中，男性的全因死亡率和癌症特异性死亡率的生存曲线比女性下降得更陡峭。在分析 PTC ＞1cm 和 PTMC 的患者时，观察到了类似的结果。在校正潜在混杂因素后，在分析所有 PTC、PTC＞1cm 和 PTMC 时，危险率表明男性的全因死亡率显著升高。然而，在对 PTMC 患者进行混杂因素校正分析时，危险率并未表明男性的死亡率显著高于女性。本研究表明，男性是所有 PTC 和 PTC＞1cm 的独立不良预后因素。然而，在 PTMC 中，性别不是特定原因死亡率的独立预后因素。
