可见光促进的肉桂酸无金属条件下的脱羧单氟和二氟甲基化反应。
Visible-Light-Enabled Decarboxylative Mono- and Difluoromethylation of Cinnamic Acids under Metal-Free Conditions.
机构信息
Anhui Provincial Laboratory of Heterocyclic Chemistry , Maanshan 243110, P. R. China.
出版信息
Org Lett. 2017 Oct 20;19(20):5501-5504. doi: 10.1021/acs.orglett.7b02129. Epub 2017 Sep 13.
PMID:28901144
Abstract
Several new mono- and difluoromethylation reactions of cinnamic acids using an Eosin Y catalytic system are reported. An efficient alkene fluoromethylation of α,β-unsaturated carboxylic acids was accomplished under ambient temperature and metal-free conditions, with a wide range of functional group tolerance. A mechanism that involves a radical process is proposed for this reaction.
摘要
报道了几种使用曙红 Y 催化体系的肉桂酸的单氟和二氟甲基化新反应。在环境温度和无金属条件下，通过烯烃氟甲基化α，β-不饱和羧酸，实现了广泛的官能团容忍度。该反应提出了一种涉及自由基过程的机制。
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