Mostafa Gamal Abdel-Hafiz, Hefnawy Mohamed Mahmoud, Al-Majed Abdulrahman
Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box 2457, Riyadh11451, Saudi Arabia.
Sensors (Basel). 2007 Dec 13;7(12):3272-3286. doi: 10.3390/s7123272.
The construction and general performance characteristics of two novelpotentiometric membrane sensors responsive to the acebutolol are described. Thesensors are based on the use of ion-association complexes of acebutolol (AC) withtetraphenylborate(TPB) (I) and phosphomolybdate(PM) (II) as exchange sites in a PVCmatrix. The sensors show a fast, stable and near- Nernstian for the mono charge cationof AC over the concentration range 1×10 - ~10 M at 25 °C over the pH range 2.0 -6.0 with cationic slope of 51.5 ± 0.5 and 53.0 ± 0.5 per concentration decade for AC-Iand AC-II sensors respectively. The lower detection limit is 6×10 M and 4×0 M withthe response time 20-30 s in the same order of both sensors. Selectivity coefficients ofAC related to a number of interfering cation and some organic compounds wereinvestigated. There are negligible interferences are caused by most of the investigatedspecies. The direct determination of 3 - 370 μg/ml of AC shows an average recovery of 99.4 and 99.5% and a mean relative standard deviation of 1 . 5 % at 100.0 μg/ml forsensor I and II respectively. The results obtained by determination of AC in tablets usingthe proposed sensors which comparable favorably with those obtained by the Britishpharmacopoeia method. In the present investigation the electrodes have been utilized asend point indicator for some precipitation titration reactions.
描述了两种新型的对醋丁洛尔有响应的电位膜传感器的构建及其一般性能特征。这些传感器基于使用醋丁洛尔（AC）与四苯硼酸盐（TPB）（I）和磷钼酸盐（PM）（II）的离子缔合络合物作为PVC基质中的交换位点。在25°C、pH范围为2.0 - 6.0时，对于AC的单电荷阳离子，传感器在1×10⁻⁶~10⁻¹ M的浓度范围内表现出快速、稳定且接近能斯特响应，AC - I和AC - II传感器的阳离子斜率分别为每浓度 decade 51.5±0.5和53.0±0.5。两种传感器的检测下限分别为6×10⁻⁷ M和4×10⁻⁷ M，响应时间为20 - 30 s。研究了AC与多种干扰阳离子和一些有机化合物的选择性系数。大多数被研究的物种造成的干扰可忽略不计。直接测定3 - 370μg/ml的AC时，传感器I和II在100.0μg/ml时的平均回收率分别为99.4%和99.5%，平均相对标准偏差为1.5%。使用所提出的传感器测定片剂中的AC所获得的结果与英国药典方法获得的结果相比具有良好的可比性。在本研究中，这些电极已被用作一些沉淀滴定反应的终点指示剂。
