Alterary Seham S, El-Tohamy Maha F, Mostafa Gamal A E, Alrabiah Haitham
Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11451, Saudi Arabia.
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Nanomaterials (Basel). 2022 Jul 5;12(13):2313. doi: 10.3390/nano12132313.
The new research presents highly conductive polymeric membranes with a large surface area to volume ratio of metal oxide nanoparticles that were used to determine atropine sulfate (AT) in commercial dosage forms. In sensing and biosensing applications, the nanomaterials zinc oxide (ZnONPs) and magnesium oxide (MgONPs) were employed as boosting potential electroactive materials. The electroactive atropine phosphotungstate (AT-PT) was created by combining atropine sulfate and phosphotungstic acid (PTA) and mixing it with polymeric polyvinyl chloride (PVC) with the plasticizer o-nitrophenyl octyl ether (-NPOE). The modified sensors AT-PT-ZnONPs or AT-PT-MgONPs showed excellent selectivity and sensitivity for the measurements of atropine with a linear concentration range of 6.0 × 10 - 1.0 × 10 and 8.0 × 10 - 1.0 × 10 mol L with regression equations of E = (56 ± 0.5) log [AT] - 294 and E = (54 ± 0.5) log [AT] - 422 for AT-PT-NPs or AT-PT-MgONPs sensors, respectively. The AT-PT coated wire sensor, on the other hand, showed a Nernstian response at 4.0 × 10 - 1.0 × 10 mol L and a regression equation E = (52.1 ± 0.2) log [AT] + 198. The methodology-recommended guidelines were used to validate the suggested modified potentiometric systems against various criteria.
这项新研究展示了具有高导电性的聚合物膜，其金属氧化物纳米颗粒的表面积与体积之比很大，用于测定商业剂型中的硫酸阿托品（AT）。在传感和生物传感应用中，纳米材料氧化锌（ZnONPs）和氧化镁（MgONPs）被用作增强电位的电活性材料。电活性阿托品磷钨酸盐（AT-PT）是通过将硫酸阿托品和磷钨酸（PTA）混合，并与带有增塑剂邻硝基苯基辛基醚（-NPOE）的聚合物聚氯乙烯（PVC）混合而制成的。修饰后的传感器AT-PT-ZnONPs或AT-PT-MgONPs在测定阿托品时表现出优异的选择性和灵敏度，线性浓度范围分别为6.0×10⁻¹.0×10和8.0×10⁻¹.0×10 mol/L，AT-PT-ZnONPs或AT-PT-MgONPs传感器的回归方程分别为E = (56 ± 0.5) log [AT] - 294和E = (54 ± 0.5) log [AT] - 422。另一方面，AT-PT涂覆的丝式传感器在4.0×10⁻¹.0×10 mol/L时表现出能斯特响应，回归方程为E = (52.1 ± 0.2) log [AT] + 198。采用方法推荐的指导方针，根据各种标准对所建议的修饰电位系统进行验证。
