快速且新颖的金属氧化物纳米粒子修饰多壁碳纳米管用于电位法检测体育赛事中禁用药物盐酸醋丁洛尔。

Fast and novel multiwalled carbon nanotubes decorated with metal oxide nanoparticles for potentiometric detection of a prohibited medication in sports acebutolol hydrochloride.

作者信息

Al-Mohaimeed Amal M, Al Omar Suliman Y, El-Tohamy Maha F

机构信息

Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh, 11495, Saudi Arabia.

Doping Research Chair, Zoology Department, College of Science, King Saud University, Riyadh University, Riyadh, 11451, Saudi Arabia.

出版信息

Heliyon. 2023 Oct 16;9(10):e20997. doi: 10.1016/j.heliyon.2023.e20997. eCollection 2023 Oct.

DOI:10.1016/j.heliyon.2023.e20997

PMID:37876475

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10590941/

Abstract

A straightforward approach for creating fast and novel potentiometric sensors that are modified with multi-walled nanotubes (MWCNTs) was described. The impact of the selective sensor's material was studied. The suggested sensors were successfully fabricated for instant and fast detection of the prohibited β-adrenoreceptor blocking agent acebutolol hydrochloride (AC) in commercial products. Acebutolol-phosphomolybdate (AC-PM) carbon paste sensor was formed by mixing AC and phosphomolybdic acid and graphite powder in the presence of -nitrophenyl octyl ether (-NPOE) as a plasticizing agent. The functionalized AC-PM-MWCNTs and AC-PM-MWCNTs-AlO nanocomposite sensors were prepared and all parameters affecting the sensors' potential responses have been investigated as well as the green synthesis of AlONPs has been characterized using various microscopic and spectroscopic techniques. AC-PM-MWCNTs and AC-PM-MWCNTs-AlO nanocomposite sensors demonstrated linearity of 1.0 × 10-1.0 × 10 and 1.0 × 10-1.0 × 10 mol L, respectively with regression equations -53.571x + 423.24 (r = 0.999) and -57.107x + 518.54 (r = 0.999). It also revealed excellent selectivity and sensitivity for the determination and quantification of AC. The developed potentiometric system was suitable for the determination of AC in bulk powder and commercial products.

摘要

描述了一种用多壁纳米管（MWCNTs）修饰来制造快速且新颖的电位传感器的直接方法。研究了选择性传感器材料的影响。所建议的传感器已成功制造出来，用于即时快速检测商业产品中违禁的β-肾上腺素能受体阻滞剂盐酸醋丁洛尔（AC）。醋丁洛尔-磷钼酸盐（AC-PM）碳糊传感器是通过在作为增塑剂的对硝基苯基辛基醚（-NPOE）存在下，将AC与磷钼酸和石墨粉混合而成。制备了功能化的AC-PM-MWCNTs和AC-PM-MWCNTs-AlO纳米复合传感器，研究了影响传感器电位响应的所有参数，并使用各种显微镜和光谱技术对AlONPs的绿色合成进行了表征。AC-PM-MWCNTs和AC-PM-MWCNTs-AlO纳米复合传感器分别在1.0×10⁻¹.0×10⁻⁵和1.0×10⁻¹.0×10⁻⁶mol/L范围内呈线性，回归方程分别为-53.571x + 423.24（r = 0.999）和-57.107x + 518.54（r = 0.999）。它还对AC的测定和定量显示出优异的选择性和灵敏度。所开发的电位系统适用于散装粉末和商业产品中AC的测定。