Department of Endocrinology, the Affiliated Hospital of Ningbo University School of Medicine, 247 Renmin Road, Ningbo, 315020, China.
Ningbo University, Ningbo, China.
Lipids Health Dis. 2017 Sep 13;16(1):175. doi: 10.1186/s12944-017-0562-y.
Hypertension and the triglyceride and glucose index both have been associated with insulin resistance; however, the longitudinal association remains unclear. This study was designed to investigate the longitudinal association between the triglyceride and glucose index and incident hypertension among the Chinese population.
We studied 4686 subjects (3177 males and 1509 females) and followed up for 9 years. The subjects were divided into four groups based on the triglyceride and glucose index. Univariate and multivariate Cox regression models were used to analyse the risk factors of hypertension.
After 9 years of follow-up, 2047 subjects developed hypertension. The overall 9-year cumulative incidence of hypertension was 43.7%, ranging from 28.5% in quartile 1 to 36.9% in quartile 2, 49.2% in quartile 3 and 59.8% in quartile 4 (p for trend < 0.001). Cox regression analyses indicated that higher triglyceride and glucose index was associated with an increased risk of subsequent incident hypertension.
The triglyceride and glucose index can predict the incident hypertension among the Chinese population.
高血压和甘油三酯与葡萄糖指数都与胰岛素抵抗有关；然而，其纵向关联尚不清楚。本研究旨在探讨中国人群中甘油三酯与葡萄糖指数与高血压事件之间的纵向关联。
我们研究了 4686 名受试者（3177 名男性和 1509 名女性），并随访了 9 年。根据甘油三酯与葡萄糖指数将受试者分为四组。使用单变量和多变量 Cox 回归模型分析高血压的危险因素。
随访 9 年后，2047 名受试者发生高血压。高血压的总 9 年累积发生率为 43.7%，从第 1 四分位组的 28.5%到第 2 四分位组的 36.9%，第 3 四分位组的 49.2%到第 4 四分位组的 59.8%（趋势 p<0.001）。Cox 回归分析表明，较高的甘油三酯与葡萄糖指数与随后发生高血压的风险增加相关。
甘油三酯与葡萄糖指数可以预测中国人群中高血压的发生。
