Celik Atac, Karayakali Metin, Altunkas Fatih, Karaman Kayihan, Arisoy Arif, Ceyhan Koksal, Kadi Hasan, Koc Fatih
Department of Cardiology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey. Email:
Department of Cardiology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.
Cardiovasc J Afr. 2017;28(5):319-323. doi: 10.5830/CVJA-2017-015. Epub 2017 Aug 23.
Previous studies have predicted an independent relationship between red cell distribution width (RDW) and the risk of death and cardiovascular events in patients with coronary artery disease (CAD). The aim of this study was to investigate the relationship between RDW and extensiveness of CAD in patients with diabetes mellitus (DM).
Two hundred and thirty-three diabetic patients who underwent coronary angiographies at our centre in 2010 were included in the study. All of the angiograms were re-evaluated and Gensini scores were calculated. Triple-vessel disease was diagnosed in the presence of stenosis > 50% in all three coronary artery systems.
RDW was significantly higher in diabetic CAD patients (p < 0.001). Patients with CAD who had a RDW value above the cut-off point also had higher Gensini scores, higher percentages of obstructive CAD and triple-vessel disease (p ≤ 0.001 for all). According to the cut-off values calculated using ROC analysis, RDW > 13.25% had a high diagnostic accuracy for predicting CAD. RDW was also positively correlated with Gensini score, obstructive CAD and triple-vessel disease (r < 0.468 and p < 0.001 for all).
RDW values were found to be increased in the diabetic CAD population. Higher RDW values were related to more extensive and complex coronary lesions in patients with DM.
先前的研究预测，红细胞分布宽度（RDW）与冠心病（CAD）患者的死亡风险和心血管事件之间存在独立关系。本研究的目的是调查糖尿病（DM）患者中RDW与CAD广泛性之间的关系。
本研究纳入了2010年在我们中心接受冠状动脉造影的233例糖尿病患者。所有血管造影均重新评估并计算Gensini评分。在所有三个冠状动脉系统中存在> 50%的狭窄时诊断为三支血管病变。
糖尿病CAD患者的RDW显著更高（p < 0.001）。RDW值高于临界点的CAD患者也有更高的Gensini评分、更高的阻塞性CAD百分比和三支血管病变百分比（所有p≤0.001）。根据使用ROC分析计算的临界值，RDW> 13.25%对预测CAD具有较高的诊断准确性。RDW也与Gensini评分、阻塞性CAD和三支血管病变呈正相关（所有r < 0.468且p < 0.001）。
发现糖尿病CAD人群的RDW值升高。较高的RDW值与DM患者更广泛和复杂的冠状动脉病变有关。
