Ren Shuai, Cai Maolin, Shi Yan, Xu Weiqing, Zhang Xiaohua Douglas
School of Automation Science and Electrical Engineering, Beihang University, Beijing, 100191, China.
Beijing Engineering Research Center of Diagnosis and Treatment of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Beijing, 100043, China.
Int J Numer Method Biomed Eng. 2018 Mar;34(3). doi: 10.1002/cnm.2929. Epub 2017 Nov 20.
Bronchial diameter is a key parameter that affects the respiratory treatment of mechanically ventilated patients. In this paper, to reveal the influence of bronchial diameter on the airflow dynamics of pressure-controlled mechanically ventilated patients, a new respiratory system model is presented that combines multigeneration airways with lungs. Furthermore, experiments and simulation studies to verify the model are performed. Finally, through the simulation study, it can be determined that in airway generations 2 to 7, when the diameter is reduced to half of the original value, the maximum air pressure (maximum air pressure in lungs) decreases by nearly 16%, the maximum flow decreases by nearly 30%, and the total airway pressure loss (sum of each generation pressure drop) is more than 5 times the original value. Moreover, in airway generations 8 to 16, with increasing diameter, the maximum air pressure, maximum flow, and total airway pressure loss remain almost constant. When the diameter is reduced to half of the original value, the maximum air pressure decreases by 3%, the maximum flow decreases by nearly 5%, and the total airway pressure loss increases by 200%. The study creates a foundation for improvement in respiratory disease diagnosis and treatment.
支气管直径是影响机械通气患者呼吸治疗的关键参数。本文为揭示支气管直径对压力控制下机械通气患者气流动力学的影响，提出了一种将多代气道与肺相结合的新型呼吸系统模型。此外，还进行了验证该模型的实验和模拟研究。最后，通过模拟研究可以确定，在第2至7代气道中，当直径减小到原来的一半时，最大气压（肺内最大气压）降低近16%，最大流量降低近30%，气道总压力损失（各代压降之和）是原来的5倍多。此外，在第8至16代气道中，随着直径的增加，最大气压、最大流量和气道总压力损失几乎保持不变。当直径减小到原来的一半时，最大气压降低3%，最大流量降低近5%，气道总压力损失增加200%。该研究为改善呼吸系统疾病的诊断和治疗奠定了基础。
