Sun Yong, Shao Yani, Zhang Zhiguo, Wang Lianfen, Mariga Alfred M, Pang Guangchang, Geng Chaoyu, Ho Chi-Tang, Hu Qiuhui, Zhao Liyan
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China; Beijing Food Research Institute, Beijing 100162, China.
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
J Food Drug Anal. 2014 Dec;22(4):463-467. doi: 10.1016/j.jfda.2014.01.025. Epub 2014 Feb 28.
Cordyceps (Cordyceps militaris) exhibits many biological activities including antioxidant, inhibition of inflammation, cancer prevention, hypoglycemic, and antiaging properties, etc. However, a majority of studies involving C. militaris have focused only on in vitro and animal models, and there is a lack of direct translation and application of study results to clinical practice (e.g., health benefits). In this study, we investigated the regulatory effects of C. militaris micron powder (3 doses) on the human immune system. The study results showed that administration of C. militaris at various dosages reduced the activity of cytokines such as eotaxin, fibroblast growth factor-2, GRO, and monocyte chemoattractant protein-1. In addition, there was a significant decrease in the activity of various cytokines, including GRO, sCD40L, and tumor necrosis factor-α, and a significant downregulation of interleukin-12(p70), interferon-γ inducible protein 10, and macrophage inflammatory protein-1β activities, indicating that C. militaris at all three dosages downregulated the activity of cytokines, especially inflammatory cytokines and chemokines. Different dosages of C. militaris produced different changes in cytokines.
蛹虫草（北虫草）具有多种生物活性，包括抗氧化、抑制炎症、预防癌症、降血糖和抗衰老等特性。然而，大多数涉及北虫草的研究仅集中在体外和动物模型上，并且缺乏将研究结果直接转化并应用于临床实践（如对健康的益处）。在本研究中，我们调查了北虫草微米粉（3种剂量）对人体免疫系统的调节作用。研究结果表明，给予不同剂量的北虫草可降低嗜酸性粒细胞趋化因子、成纤维细胞生长因子-2、生长调节致癌基因蛋白和单核细胞趋化蛋白-1等细胞因子的活性。此外，包括生长调节致癌基因蛋白、可溶性CD40配体和肿瘤坏死因子-α在内的多种细胞因子活性显著降低，白细胞介素-12（p70）、干扰素-γ诱导蛋白10和巨噬细胞炎性蛋白-1β的活性显著下调，表明所有三种剂量的北虫草均下调了细胞因子的活性，尤其是炎性细胞因子和趋化因子。不同剂量的北虫草对细胞因子产生了不同的变化。
