Eldivan Özlem, Evliyaoğlu Özlem, Ersoy Ebru, Aksu Gönül, Dilbaz Serdar, Göktolga Ümit
Etlik Zübeyde Hanım Women's Healthcare Education and Research Hospital, Clinic of Obstetrics and Gynecology, Ankara, Turkey.
Etlik Zübeyde Hanım Women's Healthcare Education and Research Hospital, Clinic of Microbiology, Ankara, Turkey.
Turk J Obstet Gynecol. 2016 Mar;13(1):11-15. doi: 10.4274/tjod.56563. Epub 2016 Mar 10.
Assisted reproduction techniques have become widespread worldwide. Considering their costs, physicians endeavor to improve pregnancy rates. Infections are one of the disrupting problems in this arena. We aimed to investigate the effects of screening for vaginal infection on pregnancy rates in intracytoplasmic sperm injection cycles.
One hundred twenty patients randomized into two groups for this study. Patients were screened for vaginal infections in group 1, and no screening was performed in group 2. The assisted reproduction outcomes were investigated and compared between the two groups.
There was no significant difference between ages, or durations and causes of infertility of patients who conceived and of those who did conceive. Forty-five patients in group 1, and 40 patients in group 2 reached the embryo transfer stage. The rates of conception were 23.5% (n=4) in culture-positive patients (n=17), and 42.9% (n=12) in culture-negative patients (n=28) in group 1. There was no significant difference among patients who were not screened, screen-positive, and screen-negative, in terms of pregnancy rates. None of the patients had Neisseria gonorrhoeae or Trichomonas vaginalis. Bacterial vaginosis was detected in 13 patients, and both bacterial vaginosis and were detected in 4 patients. Three of 4 patients who conceived screen-positive and 8 of 12 patients who conceived screen-negative delivered healthily at term.
No significant difference was found between patients who were sampled for culture and patients who were not sampled in terms of pregnancy rates. Also, no difference was found between the patients who were culture-negative and patients who were treated with antimicrobials after a culture positive result. Further larger studies are warranted to clarify this issue.
辅助生殖技术在全球范围内已广泛应用。鉴于其成本，医生们致力于提高妊娠率。感染是这一领域中令人困扰的问题之一。我们旨在研究阴道感染筛查对卵胞浆内单精子注射周期妊娠率的影响。
本研究将120例患者随机分为两组。第1组患者进行阴道感染筛查，第2组不进行筛查。对两组的辅助生殖结局进行调查和比较。
受孕患者与未受孕患者在年龄、不孕持续时间及病因方面无显著差异。第1组45例患者、第2组40例患者进入胚胎移植阶段。第1组中，培养阳性患者（n = 17）的受孕率为23.5%（n = 4），培养阴性患者（n = 28）的受孕率为42.9%（n = 12）。未筛查患者、筛查阳性患者和筛查阴性患者在妊娠率方面无显著差异。所有患者均未检测到淋病奈瑟菌或阴道毛滴虫。13例患者检测出细菌性阴道病，4例患者同时检测出细菌性阴道病和[此处原文缺失部分内容]。4例筛查阳性的受孕患者中有3例、12例筛查阴性的受孕患者中有8例足月健康分娩。
进行培养取样的患者与未取样的患者在妊娠率方面未发现显著差异。此外，培养阴性患者与培养阳性结果后接受抗菌药物治疗的患者之间也未发现差异。需要进一步开展更大规模的研究来阐明这一问题。
