van den Berg Pim J, Daoudi Khalid, Bernelot Moens Hein J, Steenbergen Wiendelt
Biomedical Photonic Imaging, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, PO Box 217, 7500 AE, Enschede, The Netherlands.
Medical Ultrasound Imaging Center, department of Radiology, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Photoacoustics. 2017 Aug 31;8:8-14. doi: 10.1016/j.pacs.2017.08.002. eCollection 2017 Dec.
We evaluate a portable ultrasound and photoacoustic imaging (PAI) system for the feasibility of a point-of-care assessment of clinically evident synovitis. Inflamed and non-inflamed proximal interphalangeal joints of 10 patients were examined and compared with joints from 7 healthy volunteers. PAI scans, ultrasound power Doppler (US-PD), and clinical examination were performed. We quantified the amount of photoacoustic (PA) signal using a region of interest (ROI) drawn over the hypertrophic joint space. PAI response was increased 4 to 10 fold when comparing inflamed with contralateral non-inflamed joints and with joints from healthy volunteers (p < 0.001 for both). US-PD and PAI were strongly correlated (Spearman's ρ = 0.64, with 95% CI: 0.42, 0.79). Hence, PAI using a compact handheld probe is capable of detecting clinically evident synovitis. This motivates further investigation into the predictive value of PAI, including multispectral PAI, with other established modalities such as US-PD or MRI.
我们评估了一种便携式超声和光声成像（PAI）系统用于对临床明显滑膜炎进行床旁评估的可行性。对10例患者的发炎和未发炎近端指间关节进行了检查，并与7名健康志愿者的关节进行了比较。进行了PAI扫描、超声功率多普勒（US-PD）检查和临床检查。我们使用在肥厚关节间隙上绘制的感兴趣区域（ROI）对光声（PA）信号量进行了量化。与对侧未发炎关节以及健康志愿者的关节相比，发炎关节的PAI反应增加了4至10倍（两者p均<0.001）。US-PD和PAI密切相关（Spearman相关系数ρ = 0.64，95%置信区间：0.42，0.79）。因此，使用紧凑型手持探头的PAI能够检测出临床明显的滑膜炎。这促使我们进一步研究PAI（包括多光谱PAI）与其他既定模式（如US-PD或MRI）相比的预测价值。
Zotero 插件