Lundquist P G, Norberg L
Department of Otorhinolaryngology, Linköping University, Sweden.
Acta Otolaryngol. 1989 May-Jun;107(5-6):434-40. doi: 10.3109/00016488909127536.
A dual innervation in salivary glands has been discussed. It is unclear how alpha-adrenergic and cholinergic agents stimulate the secretory cells. Different effects on serous and mucous cells are reported after stimulating with carbachol, clonidine, noradrenaline, cyclocytidine and pilocarpine, respectively. In the rat, carbachol and clonidine predominantly affect the mucous cells, however, with different morphological effects. Cyclocytidine exclusively degranulates the serous cells. Noradrenaline stimulates both serous and mucous cells and gives rise to vast cytoplasmic changes. Pilocarpine only shows effect on the mucous cells with formation of intracytoplasmic vacuoles. The effects reported are discussed with regard to experiments on salivary gland radiosensitivity.
唾液腺的双重神经支配已被讨论。目前尚不清楚α-肾上腺素能和胆碱能药物如何刺激分泌细胞。分别用卡巴胆碱、可乐定、去甲肾上腺素、环胞苷和毛果芸香碱刺激后，对浆液性细胞和黏液性细胞有不同影响。在大鼠中，卡巴胆碱和可乐定主要影响黏液性细胞，但形态学影响不同。环胞苷仅使浆液性细胞脱颗粒。去甲肾上腺素刺激浆液性细胞和黏液性细胞，并引起大量细胞质变化。毛果芸香碱仅对黏液性细胞有影响，导致胞质内空泡形成。就唾液腺放射敏感性的实验对所报道的这些影响进行了讨论。
