Norberg L E, Forsberg B
Department of Otolaryngology, University Hospital, Linköping, Sweden.
ORL J Otorhinolaryngol Relat Spec. 1987;49(6):302-13. doi: 10.1159/000275956.
The submaxillary glands were exposed to fractionated irradiation comparable to 50 Gy in clinical practice and a single fraction of 50 Gy. Half the number of rats were given cyclocytidine, an alpha-adrenergic agonist which depletes the serous cell granules before irradiation was embarked upon. Our results show that irradiation causes a significant, irreversible destruction of serous cells. With cyclocytidine pretreatment, the radiodamage was diminished and this drug is suggested to act as a radioprotector, depleting secretory heavy metal granules, and thus preventing radiodamage in the submaxillary salivary glands.
将下颌下腺暴露于在临床实践中相当于50 Gy的分次照射以及单次50 Gy照射。在开始照射前，给半数大鼠注射环胞苷，一种α-肾上腺素能激动剂，其可使浆液细胞颗粒耗竭。我们的结果表明，照射会导致浆液细胞发生显著的、不可逆的破坏。经环胞苷预处理后，辐射损伤减轻，提示该药物可作为辐射防护剂，通过耗竭分泌性重金属颗粒，从而防止下颌下唾液腺发生辐射损伤。
