Salinsky J V, Doré C J
J R Coll Gen Pract. 1987 May;37(298):202-4.
In a practice of 6000 patients, all long term users of day time benzodiazepine tranquillizers were identified and matched for age and sex with controls. Patients and controls were asked to complete two postal questionnaires, one to measure a number of neurotic personality traits and the other to record details of personal history thought to be relevant. Tranquillizer users were also sent a third questionnaire which surveyed their attitudes to reliance on tranquillizers. Long term users of benzodiazepines had significantly higher scores for anxiety and other neurotic traits but their personal histories showed few significant differences from those of controls. Patients reliant on benzodiazepines seem to be a distinct, more ;neurotic' sub-group of the practice population although their lives have not been any more disturbed. Most patients thought that tranquillizers had helped them but many felt uneasy about being reliant on them. Follow up showed a trend towards spontaneous discontinuing of the tablets.
在一项针对6000名患者的研究中，所有日间长期使用苯二氮䓬类镇静剂的患者均被识别出来，并按照年龄和性别与对照组进行匹配。患者和对照组被要求填写两份邮寄问卷，一份用于测量一些神经质人格特质，另一份用于记录被认为相关的个人病史细节。镇静剂使用者还收到了第三份问卷，该问卷调查了他们对依赖镇静剂的态度。长期使用苯二氮䓬类药物的患者在焦虑和其他神经质特质方面的得分显著更高，但他们的个人病史与对照组相比几乎没有显著差异。依赖苯二氮䓬类药物的患者似乎是该医疗机构人群中一个独特的、更“神经质”的亚组，尽管他们的生活并没有受到更多干扰。大多数患者认为镇静剂对他们有帮助，但许多人对依赖镇静剂感到不安。随访显示有自行停药的趋势。
