Berings D, Blondeel L, Habraken H
Project Farmaka, Gent, Belgium.
Eur J Clin Pharmacol. 1994;46(6):501-5. doi: 10.1007/BF00196105.
In order to measure the effect of industry-independent information on the prescribing of benzodiazepines in general practice, 128 primary practitioners were randomly allocated to three intervention groups after stratification by year of graduation. One third of the participating physicians were forwarded written information about the indications and limitations of benzodiazepines, another third received both written and oral information, and the remaining third (the control group) obtained no information at all. A comparison of the number of benzodiazepines prescribed per 100 patient contacts with prescription before and after the intervention showed an average decrease of 3% in the control group, of 14% in physicians who received only written information, and of 24% in physicians who were given additional oral information. Post hoc pair-wise comparisons revealed a significant difference at the 1% level in the number of benzodiazepines prescribed between physicians who received both written and oral information and the control group. A follow-up survey conducted 4 weeks after the intervention showed that the oral information campaign positively affected physicians' attitudes about the value of oral drug information from an industry-independent source.
为了衡量行业独立信息对全科医疗中苯二氮䓬类药物处方的影响，128名初级从业者在按毕业年份分层后被随机分配到三个干预组。三分之一的参与医生收到了关于苯二氮䓬类药物适应症和局限性的书面信息，另外三分之一同时收到了书面和口头信息，其余三分之一（对照组）根本没有收到任何信息。将干预前后每100次患者接触中开具的苯二氮䓬类药物数量与处方进行比较，结果显示，对照组平均减少了3%，仅收到书面信息的医生减少了14%，同时收到口头信息的医生减少了24%。事后两两比较显示，在同时收到书面和口头信息的医生与对照组之间，苯二氮䓬类药物的处方数量在1%的水平上存在显著差异。干预四周后进行的一项后续调查显示，口头信息宣传活动对医生对来自行业独立来源的口服药物信息价值的态度产生了积极影响。
