Krautkramer Kimberly A, Dhillon Rashpal S, Denu John M, Carey Hannah V
Department of Biomolecular Chemistry, University of Wisconsin - Madison, Madison, Wis; Wisconsin Institute for Discovery, Madison, Wis.
Department of Biomolecular Chemistry, University of Wisconsin - Madison, Madison, Wis; Wisconsin Institute for Discovery, Madison, Wis.
Transl Res. 2017 Nov;189:30-50. doi: 10.1016/j.trsl.2017.08.005. Epub 2017 Sep 1.
The mammalian gut microbiota has been linked to host developmental, immunologic, and metabolic outcomes. This collection of trillions of microbes inhabits the gut and produces a myriad of metabolites, which are measurable in host circulation and contribute to the pathogenesis of human diseases. The link between endogenous metabolite availability and chromatin regulation is a well-established and active area of investigation; however, whether microbial metabolites can elicit similar effects is less understood. In this review, we focus on seminal and recent research that establishes chromatin regulatory roles for both endogenous and microbial metabolites. We also highlight key physiologic and disease settings where microbial metabolite-host chromatin interactions have been established and/or may be pertinent.
哺乳动物的肠道微生物群与宿主的发育、免疫和代谢结果有关。这数万亿的微生物聚集在肠道中，并产生无数的代谢产物，这些代谢产物可在宿主循环中检测到，并导致人类疾病的发病机制。内源性代谢物的可用性与染色质调控之间的联系是一个成熟且活跃的研究领域；然而，微生物代谢物是否能产生类似的影响却鲜为人知。在这篇综述中，我们重点关注了开创性的和最新的研究，这些研究确定了内源性和微生物代谢物在染色质调控中的作用。我们还强调了已建立和/或可能相关的微生物代谢物与宿主染色质相互作用的关键生理和疾病背景。
