Talei Gholam-Reza, Mohammadi Mohsen, Bahmani Mahmoud, Kopaei Mahmoud Rafieian
Department of Microbiology, Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Department of Microbiology, Leishmaniasis Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Int J Pharm Investig. 2017 Apr-Jun;7(2):82-87. doi: 10.4103/jphi.JPHI_12_17.
Infectious diseases have always been an important health issue in human communities. In the recent years, much research has been conducted on antimicrobial effects of nature-based compounds because of increased prevalence of antibiotic resistance. The present study was conducted to investigate synergistic effect of and essential oils with ciprofloxacin, vancomycin, and gentamicin on Gram-negative and Gram-positive bacteria.
In this experimental study, the synergistic effects of and essential oils with antibiotics on (ATCC 25923), (ATCC 29212), (ATCC 8739), (ATCC 9027), (ATCC 14990), and (ATCC 7644) were studied according to broth microdilution and the MIC and fractional inhibitory concentration (FIC) of these two essential oils determined.
essential oil at 30 μg/ml could inhibit , and in combination with vancomycin, decreased MIC from 0.5 to 0.12 μg/ml. Moreover, the FIC was derived 0.24 μg/ml which represents a potent synergistic effect with vancomycin against growth. essential oil alone or combined with other antibiotics is effective in treating bacterial infections.
In addition, essential oil can strengthen the activities of certain antibiotics, which makes it possible to use this essential oil, especially in drug resistance or to lower dosage or toxicity of the drugs.
传染病一直是人类社会中的一个重要健康问题。近年来，由于抗生素耐药性的增加，人们对天然化合物的抗菌作用进行了大量研究。本研究旨在探讨[两种精油名称未给出]精油与环丙沙星、万古霉素和庆大霉素对革兰氏阴性菌和革兰氏阳性菌的协同作用。
在本实验研究中，根据肉汤微量稀释法研究了[两种精油名称未给出]精油与抗生素对大肠杆菌（ATCC 25923）、金黄色葡萄球菌（ATCC 29212）、肺炎克雷伯菌（ATCC 8739）、铜绿假单胞菌（ATCC 9027）、鲍曼不动杆菌（ATCC 14990）和嗜麦芽窄食单胞菌（ATCC 7644）的协同作用，并测定了这两种精油的最低抑菌浓度（MIC）和分数抑菌浓度（FIC）。
[一种精油名称未给出]精油在30μg/ml时可抑制[相关细菌名称未给出]，与万古霉素联合使用时，MIC从0.5μg/ml降至0.12μg/ml。此外，FIC为0.24μg/ml，表明与万古霉素对[相关细菌名称未给出]生长具有强效协同作用。[另一种精油名称未给出]精油单独使用或与其他抗生素联合使用对治疗细菌感染有效。
此外，[一种精油名称未给出]精油可增强某些抗生素的活性，这使得使用这种精油成为可能，特别是在耐药性方面或降低药物的剂量或毒性方面。
