从彭县雪胆（Hemsleya pengxianensis）根“雪胆”中分离得到的8个新葫芦烷型三萜类化合物。
Eight new cucurbitane triterpenoids from "Xue Dan," the roots of Hemsleya pengxianensis.
作者信息
Li Ying, Wang Wen-Xue, Zheng Zhong-Fei, Mu Yan-Ling, Liu Yong-Jun, Wang Hai-Yang, Li Ling, Yao Qing-Qiang
机构信息
a Institute of Materia Medica, Shandong Academy of Medical Sciences , Jinan 250062 , China.
c Key Laboratory for Biotech-Drugs Ministry of Health , Jinan 250062 , China.
出版信息
J Asian Nat Prod Res. 2018 Jan;20(1):36-48. doi: 10.1080/10286020.2017.1355363. Epub 2017 Sep 20.
Eight new natural products (four new cucurbitane aglycones, hemslepencins A-D (1-4), four new cucurbitane glucosides, hemslepensides F-I (5-8), along with seven known compounds (9-15), were isolated from the roots of Hemsleya pengxianensis. The structures of 1-8 were elucidated using IR, HRESIMS, and NMR. Compound 3 exhibited cytotoxic activity against the human cancer cell lines.
从彭县雪胆的根部分离得到8个新天然产物（4个新葫芦素苷元，雪胆素A-D（1-4）；4个新葫芦素糖苷，雪胆素苷F-I（5-8）），以及7个已知化合物（9-15）。通过红外光谱（IR）、高分辨电喷雾电离质谱（HRESIMS）和核磁共振（NMR）对化合物1-8的结构进行了鉴定。化合物3对人癌细胞系具有细胞毒活性。
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