Zhu Nailiang, Sun Zhonghao, Hu Meigeng, Li Yedan, Zhang Dawei, Wu Haifeng, Tian Yu, Li Pengfei, Yang Junshan, Ma Guoxu, Xu Xudong
Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education; Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine; Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine; Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China.
Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education; Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine; Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine; Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China; Center of Research and Development on Life Sciences and Environment Sciences, Harbin University of Commerce, Harbin, 150076, China.
Phytochemistry. 2018 Mar;147:49-56. doi: 10.1016/j.phytochem.2017.12.014. Epub 2017 Dec 26.
The tubers of the medicinal plant Hemsleya penxianensis (Cucurbitaceae) yielded 11 cucurbitane-type triterpenes Xuedanencins A-K by silica gel column, ODS column, and pre-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Separated compounds were evaluated for cytotoxic activity against the Hela human cancer cell line and compounds 7 and 8 showed significant cytotoxicity with IC values at 1.82 and 2.45 μM, respectively.
药用植物彭县雪胆（葫芦科）的块茎通过硅胶柱、ODS柱和制备型高效液相色谱技术分离得到11个葫芦烷型三萜雪胆素A-K。通过光谱分析确定了它们的结构，并与先前研究的现有数据进行了比较。对分离得到的化合物进行了针对人宫颈癌HeLa细胞系的细胞毒性活性评估，化合物7和8表现出显著的细胞毒性，IC值分别为1.82和2.45 μM。
