Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China; School of Medicine and Life Sciences, University of Jinan, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, PR China.
Bioorg Med Chem Lett. 2014 May 1;24(9):2159-62. doi: 10.1016/j.bmcl.2014.03.027. Epub 2014 Mar 20.
Two new cucurbitane glycosides, hemslepenside A (1) and 16,25-O-diacetyl-cucurbitacin F-2-O-β-d-glucopyranoside (3), one new cucurbitacin, 16-O-acetyl-cucurbitacin F (2), along with three known cucurbitane compounds, were isolated from the roots of Hemsleya penxianensis. The structures of 1-6 were established on the basis of extensive spectroscopic and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against different three human cancer cell lines, with IC50 values in the low microgram range.
从滇南雪胆（Hemsleya penxianensis）的根部分离得到了两个新的葫芦烷型糖苷，分别为 hemslepenside A（1）和 16,25-O-二乙酰基葫芦素 F-2-O-β-D-吡喃葡萄糖苷（3），一个新的葫芦素 16-O-乙酰基葫芦素 F（2），以及三个已知的葫芦烷型化合物。通过广泛的光谱和化学方法确定了 1-6 的结构。对分离得到的化合物进行了对三种不同人癌细胞系的细胞毒性活性评价，其 IC50 值均在微克级范围内。
