More Nilesh V, Kharat Arun S
Department of Biotechnology, Dr. Babasaheb Ambedkar Marathwada University, Subcampus, Osmanabad 413501, Maharashtra, India.
Department of Biotechnology, College of Computer Science and Information Technology, Latur 413512, Maharashtra, India.
Medicines (Basel). 2016 Nov 3;3(4):28. doi: 10.3390/medicines3040028.
Medicinal plants are widely used to treat infectious diseases, metabolic disorders and cancer. L. (), commonly found on desolate land of Marathwada (Maharashtra, India) has been used to treat oral cavity infections. In this study, cold aqueous and methanolic extracts were prepared from stem and leaves. These extracts were tested for their antifungal and anticancer activities. The antifungal activity was tested using the agar well diffusion method, while the anticancer activity against immortalized cell lines was assessed by trypan blue assay. It was observed that both cold aqueous and methanolic extracts of stem and leaves inhibited the growth of , , and . Antifungal activity of the extract was comparable to that of Amphoterecin-B. extracts had a cytotoxic effect on A549, SiHa and KB immortalized cell lines that were similar to that of berberine. The leaf and stems exhibit strong antifungal and anticancer potential.
药用植物被广泛用于治疗传染病、代谢紊乱和癌症。L.（）常见于印度马哈拉施特拉邦马勒什瓦达的荒凉土地上，已被用于治疗口腔感染。在本研究中，从茎和叶中制备了冷的水提取物和甲醇提取物。对这些提取物进行了抗真菌和抗癌活性测试。使用琼脂孔扩散法测试抗真菌活性，而通过台盼蓝测定法评估对永生化细胞系的抗癌活性。观察到茎和叶的冷水提取物和甲醇提取物均抑制了、、和的生长。提取物的抗真菌活性与两性霉素B相当。提取物对A549、SiHa和KB永生化细胞系具有细胞毒性作用，类似于小檗碱。该植物的叶和茎表现出很强的抗真菌和抗癌潜力。
