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体外冲击波碎石术治疗有症状输尿管结石的疗效:无需计算机断层扫描辅助的治疗失败预测因素

The efficacy of extracorporeal shockwave lithotripsy for symptomatic ureteral stones: Predictors of treatment failure without the assistance of computed tomography.

作者信息

Chiang Bing-Juin, Liao Chun-Hou, Lin Yu-Hua

机构信息

Department of Life Science, National Taiwan Normal University, Taipei, Taiwan.

Division of Urology, Department of Surgery, Cardinal Tien Hospital, New Taipei City, Taiwan.

出版信息

PLoS One. 2017 Sep 20;12(9):e0184855. doi: 10.1371/journal.pone.0184855. eCollection 2017.

Abstract

OBJECTIVES

Non-contrast computed tomography (NCCT) is not always performed clinically if the diagnosis of ureteral calculi has been confirmed using other radiographic imaging modalities. The aim of this study was to identify predictors of successful extracorporeal shockwave lithotripsy (ESWL) without assistance of NCCT.

METHODS

We retrospectively reviewed the medical records of patients with symptomatic solitary ureteral stones who underwent ESWL between November 2015 and January 2016. Abdominal plain radiography or intravenous urography were performed before ESWL for localization. The exclusion criteria were repeated sessions of ESWL for the target stone and congenital genitourinary tract anomalies. The demographic characteristics, clinical history, medical charges, or imaging features of the stones were recorded. Successful treatment was defined as no fragments detected on radiography or ultrasonography in 4 weeks. For radiolucent calculi, successful treatment was regarded as cases without hydronephrosis, symptoms, or hematuria. Patients experiencing intractable pain and undergoing subsequent auxiliary surgeries were regarded as having ESWL treatment failure.

RESULTS

Age (odds ratio [OR], 1.042; 95% confidence interval [CI], 1.007-1.078), history of ipsilateral renal or ureteral calculi episodes (OR, 2.669; 95% CI, 1.281-5.687), stone burden (OR, 3.499; 95% CI, 1.284-9.530), and radiopaque stone (OR, 2.351; 95% CI, 1.049-5.267) were significant predictors of ESWL failure in all patients.

CONCLUSIONS

For treating symptomatic ureteral stones, those with smaller size, radiolucency, and without a history of ipsilateral renal or ureteral calculi could be considered for first-line therapy with ESWL.

摘要

目的

如果已通过其他放射成像方式确诊输尿管结石,临床上并不总是进行非增强计算机断层扫描(NCCT)。本研究的目的是确定在无NCCT辅助的情况下体外冲击波碎石术(ESWL)成功的预测因素。

方法

我们回顾性分析了2015年11月至2016年1月期间接受ESWL治疗的有症状孤立性输尿管结石患者的病历。在ESWL前进行腹部平片或静脉肾盂造影以定位结石。排除标准为针对目标结石进行多次ESWL治疗以及先天性泌尿生殖道异常。记录患者的人口统计学特征、临床病史、医疗费用或结石的影像学特征。成功治疗定义为在4周时X线或超声检查未发现结石碎片。对于透X线结石,成功治疗被视为无肾盂积水、症状或血尿的病例。经历顽固性疼痛并接受后续辅助手术的患者被视为ESWL治疗失败。

结果

年龄(优势比[OR],1.042;95%置信区间[CI],1.007 - 1.078)、同侧肾或输尿管结石发作史(OR,2.669;95% CI,1.281 - 5.687)、结石负荷(OR,3.499;95% CI,1.284 - 9.530)和不透X线结石(OR,2.351;95% CI,1.049 - 5.267)是所有患者ESWL失败的显著预测因素。

结论

对于有症状的输尿管结石治疗,结石体积较小、透X线且无同侧肾或输尿管结石发作史的患者可考虑作为ESWL一线治疗对象。

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