Regenerative Medicine Laboratory, University of Bristol, Bristol BS8 1TD, UK.
School of Chemistry, University of Bristol, Bristol BS8 1TS, UK
J R Soc Interface. 2017 Sep;14(134). doi: 10.1098/rsif.2017.0382.
Progress made in the last two decades in chemical vapour deposition technology has enabled the production of inexpensive, high-quality coatings made from diamond to become a scientific and commercial reality. Two properties of diamond make it a highly desirable candidate material for biomedical applications: first, it is bioinert, meaning that there is minimal immune response when diamond is implanted into the body, and second, its electrical conductivity can be altered in a controlled manner, from insulating to near-metallic. diamond can be used as a substrate upon which a range of biological cells can be cultured. , diamond thin films have been proposed as coatings for implants and prostheses. Here, we review a large body of data regarding the use of diamond substrates for cell culture. We also detail more recent work exploring diamond-coated implants with the main targets being bone and neural tissue. We conclude that diamond emerges as one of the major new biomaterials of the twenty-first century that could shape the way medical treatment will be performed, especially when invasive procedures are required.
在过去的二十年中,化学气相沉积技术取得了进展,使得从廉价的高质量金刚石涂层的生产成为科学和商业现实。金刚石有两个特性使其成为生物医学应用的理想候选材料:首先,它是生物惰性的,这意味着当金刚石植入体内时,免疫反应最小;其次,其电导率可以以可控的方式从绝缘变为近金属。金刚石可用作基底,其上可以培养多种生物细胞。因此,金刚石薄膜已被提议用作植入物和假体的涂层。在这里,我们回顾了大量关于金刚石基底用于细胞培养的数据。我们还详细介绍了最近探索金刚石涂层植入物的工作,主要目标是骨骼和神经组织。我们得出的结论是,金刚石作为 21 世纪的主要新型生物材料之一脱颖而出,它可能会改变医疗方式,特别是在需要进行侵入性手术的情况下。