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用于民族兽医学的某些植物的伤口愈合特性。

Wound Healing Properties of Selected Plants Used in Ethnoveterinary Medicine.

作者信息

Marume Amos, Matope Gift, Katsande Simbarashe, Khoza Star, Mutingwende Isaac, Mduluza Takafira, Munodawafa-Taderera Tafadzwa, Ndhlala Ashwell R

机构信息

Department of Paraclinical Veterinary Studies, Faculty of Veterinary Science, University of ZimbabweHarare, Zimbabwe.

Pharmacy Skills Training and Development Unit, EastEnd Medical Centre, Harare Institute of Public HealthHarare, Zimbabwe.

出版信息

Front Pharmacol. 2017 Sep 6;8:544. doi: 10.3389/fphar.2017.00544. eCollection 2017.

Abstract

Plants have arrays of phytoconstituents that have wide ranging biological effects like antioxidant, anti-inflammatory and antimicrobial properties key in wound management. wound healing properties of ointments made of crude methanolic extracts (10% extract w/w in white soft paraffin) of three plant species, L. (whole aerial plant parts), Klotzsch (whole aerial plant parts) and Lam. Ex DC. (leaves and bark) used in ethnoveterinary medicine were evaluated on BALB/c female mice based on wound area changes, regular observations, healing skin's percentage crude protein content and histological examinations. White soft paraffin and 3% oxytetracycline ointment were used as negative and positive controls, respectively. Wound area changes over a 15 day period for mice treated with and extract ointments were comparable to those of the positive control (oxytetracycline ointment). Wounds managed with the same extract ointments exhibited high crude protein contents, similar to what was observed on animals treated with the positive control. Histological evaluations revealed that had superior wound healing properties with the wound area completely returning to normal skin structure by day 15 of the experiment. leaf and bark extract ointments exhibited lower wound healing properties though the leaf extract exhibited some modest healing properties.

摘要

植物含有一系列植物成分,这些成分具有广泛的生物学效应,如抗氧化、抗炎和抗菌特性,这些特性在伤口处理中至关重要。对用于民族兽医学的三种植物物种,即L.(地上全株部分)、Klotzsch(地上全株部分)和Lam. Ex DC.(叶和树皮)的粗甲醇提取物(在白色软石蜡中10%提取物w/w)制成的软膏的伤口愈合特性,基于伤口面积变化、定期观察、愈合皮肤的粗蛋白含量百分比和组织学检查,在BALB/c雌性小鼠上进行了评估。白色软石蜡和3%土霉素软膏分别用作阴性和阳性对照。用提取物软膏处理的小鼠在15天内的伤口面积变化与阳性对照(土霉素软膏)相当。用相同提取物软膏处理的伤口显示出高粗蛋白含量,类似于在接受阳性对照处理的动物身上观察到的情况。组织学评估显示,在实验第15天时,其伤口愈合特性优越,伤口面积完全恢复到正常皮肤结构。叶和树皮提取物软膏的伤口愈合特性较低,尽管叶提取物表现出一些适度的愈合特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efb3/5592899/df9baa02e118/fphar-08-00544-g0001.jpg

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