Biological Program, School of Distance Education, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.
Molecules. 2011 Jun 23;16(6):5268-82. doi: 10.3390/molecules16065268.
Cassia fistula is widely used in traditional medicine to treat various types of ailments. The evaluation of toxic properties of C. fistula is crucial when considering public health protection because exposure to plant extracts can result in undesirable effects on consumers. Hence, in this study the acute oral toxicity of C. fistula seeds extract was investigated in mice.
Oral administration of crude extract at the highest dose of 5000 mg/kg resulted in no mortalities or evidence of adverse effects, implying that C. fistula in nontoxic. Throughout 14 days of the treatment no changes in behavioural pattern, clinical sign and body weight of mice in both control and treatment groups. Also there were no any significant elevations observed in the biochemical analysis of the blood serum. Further, histopathological examination revealed normal architecture and no significant adverse effects observed on the kidney, heart, liver, lung and spleen.
Overall, the results suggest that, the oral administration of C. fistula methanolic seeds extract did not produce any significant toxic effect in mice. Hence, the extract can be utilized for pharmaceutical formulations.
木豆广泛应用于传统医学，用于治疗各种疾病。考虑到公众健康保护，评估木豆的毒性特性至关重要，因为接触植物提取物可能会对消费者产生不良影响。因此，本研究旨在评估木豆种子提取物的急性经口毒性。
在最高剂量 5000mg/kg 的情况下，给予粗提取物未导致任何死亡或不良反应的证据，表明木豆无毒。在治疗的 14 天内，对照组和治疗组的小鼠的行为模式、临床症状和体重均无变化。血清生化分析也没有观察到任何显著升高。此外，组织病理学检查显示肾脏、心脏、肝脏、肺脏和脾脏的结构正常，没有观察到明显的不良反应。
总体而言，结果表明，木豆甲醇种子提取物经口给予小鼠未产生明显的毒性作用。因此，该提取物可用于药物制剂。
