Masrour-Roudsari Jila, Ebrahimpour Soheil
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Caspian J Intern Med. 2017 Summer;8(3):153-158. doi: 10.22088/cjim.8.3.153.
Cancer is a complex group of diseases with multiple eventual causes. The underlying causes are not fully known. Thus, learning more about the known causes of cancer is an important issue. Moreover, among these factors, infection and its association to cancers is controversial. Although, it seems that the genome instability of the cells can initiate cancer development. The purpose of this review was to present the role of infection in the development of cancer. Infectious agents, such as hepatitis B (HBV) and C viruses (HCV), Epstein-Barr virus (EBV), human papillomavirus (HPV), human immunodeficiency virus type 1 (HIV-1), Helicobacter pylori (H. pylori) and Streptococcus bovis (S. bovis) contribute to the pathogenesis of different cancers. These cancers include hepatocellular carcinoma, Burkitt's lymphoma, nasopharyngeal carcinoma, cervical cancers, non-Hodgkin lymphoma, Kaposi sarcoma, adenocarcinoma and lymphoma. Screenings of infectious diseases in cancer patients may open up areas of research in the identification of optimizing cancer control strategies.
癌症是一组复杂的疾病，有多种最终病因。其根本原因尚未完全明确。因此，更多地了解已知的癌症病因是一个重要问题。此外，在这些因素中，感染及其与癌症的关联存在争议。尽管如此，细胞的基因组不稳定性似乎能够引发癌症的发展。本综述的目的是阐述感染在癌症发展中的作用。诸如乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）、爱泼斯坦-巴尔病毒（EBV）、人乳头瘤病毒（HPV）、1型人类免疫缺陷病毒（HIV-1）、幽门螺杆菌（H. pylori）和牛链球菌（S. bovis）等感染因子会导致不同癌症的发病机制。这些癌症包括肝细胞癌、伯基特淋巴瘤、鼻咽癌、宫颈癌、非霍奇金淋巴瘤、卡波西肉瘤、腺癌和淋巴瘤。对癌症患者进行传染病筛查可能会为确定优化癌症控制策略的研究开辟新领域。
