从锦葵科植物中分离得到的芙蓉酸和芙蓉酸二甲酯的晶体结构。
Crystal structures of hibiscus acid and hibiscus acid dimethyl ester isolated from (Malvaceae).
作者信息
Zheoat Ahmed M, Gray Alexander I, Igoli John O, Kennedy Alan R, Ferro Valerie A
机构信息
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland.
Westchem, Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, Scotland.
出版信息
Acta Crystallogr E Crystallogr Commun. 2017 Aug 21;73(Pt 9):1368-1371. doi: 10.1107/S2056989017011902. eCollection 2017 Sep 1.
The biologically active title compounds have been isolated from plants, hibiscus acid as a dimethyl sulfoxide monosolvate [systematic name: (2,3)-3-hy-droxy-5-oxo-2,3,4,5-tetra-hydro-furan-2,3-di-carb-oxy-lic acid dimethyl sulfoxide monosolvate], CHO·CHOS, (I), and hibiscus acid dimethyl ester [systematic name: dimethyl (2,3)-3-hy-droxy-5-oxo-2,3,4,5-tetra-hydro-furan-2,3-di-carboxyl-ate], CHO, (II). Compound (I) forms a layered structure with alternating layers of lactone and solvent mol-ecules, that include a two-dimensional hydrogen-bonding construct. Compound (II) has two crystallographically independent and conformationally similar mol-ecules per asymmetric unit and forms a one-dimensional hydrogen-bonding construct. The known absolute configuration for both compounds has been confirmed.
具有生物活性的标题化合物已从植物中分离得到，芙蓉酸以二甲基亚砜单溶剂合物[系统名称：(2,3)-3-羟基-5-氧代-2,3,4,5-四氢呋喃-2,3-二羧酸二甲基亚砜单溶剂合物]，CHO·CHOS，(I)，以及芙蓉酸二甲酯[系统名称：二甲基(2,3)-3-羟基-5-氧代-2,3,4,5-四氢呋喃-2,3-二羧酸酯]，CHO，(II)的形式存在。化合物(I)形成了一种层状结构，其中内酯层和溶剂分子层交替排列，包括一种二维氢键结构。化合物(II)每个不对称单元有两个晶体学独立且构象相似的分子，并形成一种一维氢键结构。两种化合物的已知绝对构型已得到确认。
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