Martinez-Carreres Laia, Nasrallah Anita, Fajas Lluis
Cancer and Metabolism Laboratory, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Front Oncol. 2017 Sep 6;7:204. doi: 10.3389/fonc.2017.00204. eCollection 2017.
Membrane-bound organelles are integrated into cellular networks and work together for a common goal: regulating cell metabolism, cell signaling pathways, cell fate, cellular maintenance, and pathogen defense. Many of these interactions are well established, but little is known about the interplay between mitochondria and lysosomes, and their deregulation in cancer. The present review focuses on the common signaling pathways of both organelles, as well as the processes in which they both physically interact, their changes under pathological conditions, and the impact on targeting those organelles for treating cancer.
膜结合细胞器整合到细胞网络中，共同为一个共同目标发挥作用：调节细胞代谢、细胞信号通路、细胞命运、细胞维持和病原体防御。其中许多相互作用已得到充分证实，但对于线粒体与溶酶体之间的相互作用及其在癌症中的失调情况却知之甚少。本综述重点关注这两种细胞器的共同信号通路，以及它们在物理上相互作用的过程、病理条件下的变化，以及靶向这些细胞器治疗癌症的影响。
