Kornmann Verena N N, van Vugt Jeroen L A, Smits Anke B, van Ramshorst Bert, Boerma Djamila
Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
Ann Coloproctol. 2017 Aug;33(4):134-138. doi: 10.3393/ac.2017.33.4.134. Epub 2017 Aug 31.
Surgery for colorectal malignancy is increasingly being performed in the elderly. Little is known about the impact of complications on late mortality. This study aimed to analyze whether a complicated postoperative course affects the 1-year survival in elderly patients.
All consecutive patients older than 75 years of age who underwent colorectal cancer surgery between January 2009 and April 2013 were included in this study. The main outcome was mortality at 1 year after surgery. Logistic regression analyses were performed to determine risk factors for a poor outcome (mortality) after survival of the early postoperative course of surgery at 1-year follow-up. Patients who died within 30 days postoperatively were excluded from analysis.
The early mortality rate was 6.3% (n = 15), and 2 patients died during follow-up as a result of complications after a second surgery. A total of 223 patients survived the perioperative period and were included in this study. Twenty-two patients (9.9%) died during the first year of follow-up. Stage IV disease (P = 0.002), complications of primary surgery (P = 0.016), and comorbidity (P = 0.050) were risk factors for 1-year mortality. Intensive care unit stay, reoperation and readmission were not associated with a worse 1-year outcome.
Elderly patients with stage IV disease at the time of surgery, comorbidity, and postoperative complications are at risk for mortality during the first year after surgery. A patient-tailored approach with special attention to perioperative care should be considered in the elderly.
老年患者接受结直肠癌手术的情况日益增多。关于并发症对晚期死亡率的影响,人们了解甚少。本研究旨在分析术后病程复杂是否会影响老年患者的1年生存率。
本研究纳入了2009年1月至2013年4月期间接受结直肠癌手术的所有连续75岁以上患者。主要结局指标为术后1年的死亡率。进行逻辑回归分析以确定术后早期病程存活至1年随访时预后不良(死亡)的危险因素。术后30天内死亡的患者被排除在分析之外。
早期死亡率为6.3%(n = 15),2例患者在二次手术后因并发症在随访期间死亡。共有223例患者度过围手术期并纳入本研究。22例患者(9.9%)在随访的第一年死亡。IV期疾病(P = 0.002)、初次手术并发症(P = 0.016)和合并症(P = 0.050)是1年死亡率的危险因素。入住重症监护病房、再次手术和再次入院与1年预后较差无关。
手术时处于IV期疾病、合并症以及术后并发症的老年患者在术后第一年有死亡风险。对于老年患者,应考虑采用针对个体的方法并特别关注围手术期护理。