Buscemi Silvio, Corleo Davide, Buscemi Carola, Giordano Carla
Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), University of Palermo, Palermo, Italy.
Unit of Malattie Endocrine, del Ricambio e della Nutrizione, AOU Policlinico "P. Giaccone", Piazza delle cliniche 2, 90127, Palermo, Italy.
Eat Weight Disord. 2018 Aug;23(4):431-442. doi: 10.1007/s40519-017-0431-8. Epub 2017 Sep 20.
Irisin, a novel myokine produced in response to physical activity, promotes white-to-brown fat transdifferentiation. The name irisin referred to the ancient Greek goddess Iris, the messenger who delivered (bad) news from the gods. In mice, it has been demonstrated that irisin plays a key role in metabolic regulation, energy expenditure and glucose homeostasis. New findings from various studies carried out in both animals and humans suggest that irisin might also have other favorable effects, such as increasing bone cortical mass, preventing hepatic lipid accumulation, and improving cognitive functions, thus mediating many exercise-induced health benefits. However, data on the role and function of irisin in humans have prompted controversy, due mostly to the only recent confirmation of the presence of irisin in humans. Another strong limitation to the understanding of irisin mechanisms of action is the lack of knowledge about its receptor, which until now remains unidentified in humans and in animals. This review presents an overall analysis of the history of irisin, its expression, and its involvement in health, especially in humans. Level of Evidence Level V, review.
鸢尾素是一种因身体活动而产生的新型肌动蛋白，可促进白色脂肪向棕色脂肪的转分化。鸢尾素这个名字源自古希腊女神伊里斯，她是从众神那里传递（坏）消息的使者。在小鼠身上，已证实鸢尾素在代谢调节、能量消耗和葡萄糖稳态中起关键作用。在动物和人类身上开展的各种研究的新发现表明，鸢尾素可能还具有其他有益作用，比如增加骨皮质质量、防止肝脏脂质堆积以及改善认知功能，从而介导许多运动带来的健康益处。然而，关于鸢尾素在人类中的作用和功能的数据引发了争议，主要原因是直到最近才证实人类体内存在鸢尾素。对鸢尾素作用机制理解的另一个重大局限是缺乏对其受体的了解，到目前为止，在人类和动物中仍未确定其受体。本综述对鸢尾素的历史、表达及其对健康的影响，尤其是对人类健康的影响进行了全面分析。证据级别：V级，综述。
