NMD因子UPF3B在翻译终止中发现新功能。
New functions in translation termination uncovered for NMD factor UPF3B.
作者信息
Mühlemann Oliver, Karousis Evangelos D
机构信息
Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
出版信息
EMBO J. 2017 Oct 16;36(20):2928-2930. doi: 10.15252/embj.201798063. Epub 2017 Sep 21.
Abstract
Despite a wealth of biochemical data, the mechanism by which targets of the nonsense‐mediated mRNA decay (NMD) pathway are recognized during translation termination remains elusive. A new study by Neu‐Yilik (2017) using a fully reconstituted translation termination system reveals new roles for the NMD factor UPF3B in translation termination and a direct interaction between UPF3B and ribosome release factors.
摘要
尽管有大量的生化数据，但在翻译终止过程中，无义介导的mRNA衰变（NMD）途径的靶标被识别的机制仍然不清楚。Neu‐Yilik（2017年）使用完全重组的翻译终止系统进行的一项新研究揭示了NMD因子UPF3B在翻译终止中的新作用，以及UPF3B与核糖体释放因子之间的直接相互作用。
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2
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Nucleic Acids Res. 2016 Sep 19;44(16):7766-76. doi: 10.1093/nar/gkw635. Epub 2016 Jul 14.
3
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